Steil Garry M, Rebrin Kerstin
Medtronic MiniMed, Northridge, CA 91325, USA.
Expert Opin Drug Deliv. 2005 Mar;2(2):353-62. doi: 10.1517/17425247.2.2.353.
Closed-loop insulin delivery in individuals with diabetes can potentially lead to near-normal glucose profiles. To this end, existing subcutaneous glucose sensors and external insulin pumps can be linked with an insulin delivery algorithm to create a completely automated closed-loop system. This paper reviews current research into the development of such a system, with particular emphasis on creating a system emulating the physiological properties of the beta-cell. Issues related to using subcutaneous interstitial fluid for glucose sensing and insulin delivery are reviewed. Criteria for optimising the system are discussed using historical data. Existing strategies for open-loop pump therapy are presented with the objective of defining a path to advance from the existing physician/patient determined insulin therapy to a completely automated system.
糖尿病患者的闭环胰岛素给药有可能使血糖水平接近正常。为此，现有的皮下葡萄糖传感器和外部胰岛素泵可与胰岛素给药算法相连，以创建一个完全自动化的闭环系统。本文综述了当前对此类系统开发的研究，特别强调创建一个模拟β细胞生理特性的系统。文中还综述了与使用皮下组织间液进行葡萄糖传感和胰岛素给药相关的问题。利用历史数据讨论了优化该系统的标准。介绍了现有的开环泵治疗策略，目的是确定一条从现有的由医生/患者决定的胰岛素治疗方法迈向完全自动化系统的路径。
