闭环胰岛素输送在 1 型糖尿病中的应用。
Closed-loop insulin delivery in type 1 diabetes.
机构信息
Institute of Metabolic Science, Addenbrookes Hospital, University of Cambridge, Box 289, Level 4, Cambridge CB2 0QQ, UK.
出版信息
Endocrinol Metab Clin North Am. 2012 Mar;41(1):105-17. doi: 10.1016/j.ecl.2011.12.003.
Abstract
Advances in diabetes technology have led to significant improvements in the quality of life and care received by individuals with diabetes. Despite this, achieving tight glycemic control through intensive insulin therapy and modern insulin regimens is challenging because of the barrier of hypoglycemia, the most feared complication of insulin therapy as reported by patients, caregivers, and physicians. This article outlines the individual components of the closed-loop system together with the existing clinical evidence. The artificial pancreas prototypes currently used in clinical studies are reviewed as well as obstacles and limitations facing the technology.
摘要
糖尿病技术的进步显著改善了糖尿病患者的生活质量和护理水平。尽管如此，通过强化胰岛素治疗和现代胰岛素方案实现严格的血糖控制仍然具有挑战性，因为低血糖是胰岛素治疗最令患者、护理人员和医生担心的并发症。本文概述了闭环系统的各个组成部分以及现有的临床证据。还回顾了目前在临床研究中使用的人工胰腺原型，以及该技术面临的障碍和限制。
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