Bhisitkul R B, Keller C G
Beckman Vision Center, Department of Ophthalmology, University of California San Francisco, 10 Koret Way, K301, San Francisco, CA 94143, USA.
Br J Ophthalmol. 2005 Dec;89(12):1586-8. doi: 10.1136/bjo.2005.075853.
To develop silicon microforceps for intraocular surgery using Microelectromechanical Systems (MEMS) technology, the application of microchip fabrication techniques for the production of controllable three dimensional devices on the micrometre scale.
Prototype MEMS forceps were designed and manufactured for intraocular surgery. Scanning electron microscopy was used to evaluate device tip construction. Designs using both thermal expansion actuators and conventional mechanical activation were tested in human cadaver eyes and in vivo rabbit eyes to assess functionality in standard vitreoretinal surgery.
MEMS forceps were constructed with various tip designs ranging from 100 mum to 2 mm in length. Scanning electron microscopy confirmed accurate construction of micro features such as forceps teeth as small as tens of micrometres. In surgical testing, the silicon forceps tips were effective in surgical manoeuvres, including grasping retinal membranes and excising tissue. The mechanical actuator design on a 20 gauge handle was more operational in the intraocular environment than the thermal expansion actuator design. While handheld operation was possible, the precision of the forceps was best exploited when mounted on a three axis micromanipulator.
MEMS microforceps are feasible for conventional vitreoretinal surgery, and offer advances in terms of small scale, operating precision, and construction tolerance.
利用微机电系统(MEMS)技术开发用于眼内手术的硅微镊子,这是一种应用微芯片制造技术在微米尺度上生产可控三维装置的方法。
设计并制造了用于眼内手术的MEMS镊子原型。使用扫描电子显微镜评估器械尖端结构。在人类尸体眼和活体兔眼中测试了使用热膨胀致动器和传统机械激活的设计,以评估其在标准玻璃体视网膜手术中的功能。
构建了具有各种尖端设计的MEMS镊子,长度范围从100微米到2毫米。扫描电子显微镜证实了诸如小至几十微米的镊子齿等微特征的精确构建。在手术测试中,硅镊子尖端在手术操作中有效,包括抓取视网膜膜和切除组织。20号手柄上的机械致动器设计在眼内环境中比热膨胀致动器设计更易于操作。虽然可以手动操作,但将镊子安装在三轴微操作器上时,其精度能得到最佳发挥。
MEMS微镊子在传统玻璃体视网膜手术中是可行的,并且在小尺寸、操作精度和制造公差方面取得了进展。