感染刚果锥虫的高度易感小鼠中库普弗细胞功能受损。
Impaired Kupffer cells in highly susceptible mice infected with Trypanosoma congolense.
作者信息
Shi Meiqing, Wei Guojian, Pan Wanling, Tabel Henry
机构信息
Department of Veterinary Microbiology, WCVM, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan, S7N 5B4, Canada.
出版信息
Infect Immun. 2005 Dec;73(12):8393-6. doi: 10.1128/IAI.73.12.8393-8396.2005.
Abstract
In highly susceptible BALB/c mice infected with Trypanosoma congolense, the total number of Kupffer cells in the liver remains constant; however, their mean size increases fivefold towards the terminal stage. About 25% of Kupffer cells undergo apoptosis. We suggest that development of an impairment of the macrophage system might be a major mechanism for inefficient elimination of trypanosomes.
摘要
在感染刚果锥虫的高度易感BALB/c小鼠中，肝脏库普弗细胞的总数保持不变；然而，在终末期其平均大小增加了五倍。约25%的库普弗细胞发生凋亡。我们认为巨噬细胞系统功能障碍的发展可能是锥虫清除效率低下的主要机制。
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