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感染刚果锥虫的高度易感小鼠中库普弗细胞功能受损。

Impaired Kupffer cells in highly susceptible mice infected with Trypanosoma congolense.

作者信息

Shi Meiqing, Wei Guojian, Pan Wanling, Tabel Henry

机构信息

Department of Veterinary Microbiology, WCVM, University of Saskatchewan, 52 Campus Drive, Saskatoon, Saskatchewan, S7N 5B4, Canada.

出版信息

Infect Immun. 2005 Dec;73(12):8393-6. doi: 10.1128/IAI.73.12.8393-8396.2005.

DOI:10.1128/IAI.73.12.8393-8396.2005
PMID:16299337
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1307053/
Abstract

In highly susceptible BALB/c mice infected with Trypanosoma congolense, the total number of Kupffer cells in the liver remains constant; however, their mean size increases fivefold towards the terminal stage. About 25% of Kupffer cells undergo apoptosis. We suggest that development of an impairment of the macrophage system might be a major mechanism for inefficient elimination of trypanosomes.

摘要

在感染刚果锥虫的高度易感BALB/c小鼠中，肝脏库普弗细胞的总数保持不变；然而，在终末期其平均大小增加了五倍。约25%的库普弗细胞发生凋亡。我们认为巨噬细胞系统功能障碍的发展可能是锥虫清除效率低下的主要机制。

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本文引用的文献

1
Trypanosoma congolense infections: antibody-mediated phagocytosis by Kupffer cells.刚果锥虫感染：库普弗细胞介导的抗体吞噬作用。
J Leukoc Biol. 2004 Aug;76(2):399-405. doi: 10.1189/jlb.1003500. Epub 2004 May 10.
2
Experimental African trypanosomiasis: IFN-gamma mediates early mortality.实验性非洲锥虫病：γ干扰素介导早期死亡。
Eur J Immunol. 2003 Jan;33(1):108-18. doi: 10.1002/immu.200390013.
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Susceptibility and resistance to Trypanosoma congolense infections.对刚果锥虫感染的易感性和抗性。
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Innate resistance to Trypanosoma congolense infections: differential production of nitric oxide by macrophages from susceptible BALB/c and resistant C57Bl/6 mice.对刚果锥虫感染的天然抵抗力：易感的BALB/c小鼠和抗性的C57Bl/6小鼠巨噬细胞一氧化氮的差异产生
Exp Parasitol. 1999 Jun;92(2):131-43. doi: 10.1006/expr.1999.4408.
5
Involvement of Fas/Fas ligand system-mediated apoptosis in the development of concanavalin A-induced hepatitis.Fas/Fas配体系统介导的细胞凋亡在伴刀豆球蛋白A诱导的肝炎发生中的作用。
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Experimental murine Trypanosoma congolense infections. I. Administration of anti-IFN-gamma antibodies alters trypanosome-susceptible mice to a resistant-like phenotype.实验性小鼠刚果锥虫感染。I. 给予抗γ干扰素抗体可使对锥虫易感的小鼠转变为类似抗性的表型。
J Immunol. 1998 Nov 15;161(10):5507-15.
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Proapoptotic activity of a Trypanosoma cruzi ceramide-containing glycolipid turned on in host macrophages by IFN-gamma.一种含神经酰胺的克氏锥虫糖脂的促凋亡活性在宿主巨噬细胞中被γ干扰素激活。
J Immunol. 1998 Nov 1;161(9):4909-16.
8
II. Alcoholic liver injury involves activation of Kupffer cells by endotoxin.二、酒精性肝损伤涉及内毒素激活库普弗细胞。
Am J Physiol. 1998 Oct;275(4):G605-11. doi: 10.1152/ajpgi.1998.275.4.G605.
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Lipopolysaccharide induces disseminated endothelial apoptosis requiring ceramide generation.脂多糖诱导弥散性内皮细胞凋亡，这一过程需要神经酰胺的生成。
J Exp Med. 1997 Dec 1;186(11):1831-41. doi: 10.1084/jem.186.11.1831.
10
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