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在肺内，腺病毒介导的KARAP/DAP12过表达可增强侵袭性曲霉病期间的真菌清除率。

Intrapulmonary, adenovirus-mediated overexpression of KARAP/DAP12 enhances fungal clearance during invasive aspergillosis.

作者信息

Carpenter Kristin J, Buckland Karen F, Xing Zhou, Hogaboam Cory M

机构信息

Department of Pathology, University of Michigan Medical School, Rm. 5216B, Med. Sci. I, 1301 Catherine Road, Ann Arbor, MI 48109-0602, USA.

出版信息

Infect Immun. 2005 Dec;73(12):8402-6. doi: 10.1128/IAI.73.12.8402-8406.2005.

DOI:10.1128/IAI.73.12.8402-8406.2005
PMID:16299339
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1307040/
Abstract

Herein, we report that the intrapulmonary delivery of an adenovirus vector expressing KARAP/DAP12, an adaptor protein expressed in granulocytes and mononuclear cells, enhanced fungal clearance during experimental invasive pulmonary aspergillosis in neutropenic mice.

摘要

在此，我们报告，在中性粒细胞减少的小鼠实验性侵袭性肺曲霉病期间，表达KARAP/DAP12（一种在粒细胞和单核细胞中表达的衔接蛋白）的腺病毒载体经肺内递送可增强真菌清除。

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本文引用的文献

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Expression of TREM-1 mRNA in acute pancreatitis.急性胰腺炎中触发受体表达分子-1（TREM-1）信使核糖核酸（mRNA）的表达
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