肿瘤坏死因子α的中和作用可抑制抗原特异性1型细胞因子反应，并逆转免疫豚鼠T淋巴细胞与感染巨噬细胞共培养物中对分枝杆菌存活的抑制作用。
Neutralization of tumor necrosis factor alpha suppresses antigen-specific type 1 cytokine responses and reverses the inhibition of mycobacterial survival in cocultures of immune guinea pig T lymphocytes and infected macrophages.
作者信息
Cho Hyosun, McMurray David N
机构信息
Department of Microbial and Molecular Pathogenesis, The Texas A&M University System Health Science Center, 407 Reynolds Medical Building, College Station, TX 77843-1114, USA.
出版信息
Infect Immun. 2005 Dec;73(12):8437-41. doi: 10.1128/IAI.73.12.8437-8441.2005.
Abstract
Neutralization of tumor necrosis factor alpha (TNF-alpha) significantly down-regulated antigen-induced lymphoproliferation and the expression of interleukin-12 p40 and gamma interferon mRNA and enhanced the viability of intracellular attenuated and virulent mycobacteria in cocultures of immune T cells and macrophages obtained from Mycobacterium bovis BCG-vaccinated guinea pigs. This suggests the crucial role of TNF-alpha in the activation of a type 1 T-cell response against Mycobacterium tuberculosis infection.
摘要
肿瘤坏死因子α（TNF-α）的中和作用显著下调了抗原诱导的淋巴细胞增殖以及白细胞介素-12 p40和γ干扰素mRNA的表达，并增强了从卡介苗接种的豚鼠获得的免疫T细胞和巨噬细胞共培养物中细胞内减毒和有毒力分枝杆菌的活力。这表明TNF-α在激活针对结核分枝杆菌感染的1型T细胞应答中起关键作用。
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