Innocenzi D, Balzani A, Lupi F, Panetta C, Skroza N, Cantoresi F, Schwartz R A, Calvieri S
Dermatology and Plastic Surgery, University La Sapienza, Rome, Italy.
J Surg Oncol. 2005 Dec 15;92(4):344-6. doi: 10.1002/jso.20383.
Sebaceous carcinoma is an unusual, aggressive, malignant tumor derived from the epithelium of sebaceous glands. It may arise in ocular or extra-ocular sites and is often evident as an ulcerated or non-ulcerated cystic nodule measuring up to 8 cm in diameter. A significant number of extra-ocular sebaceous carcinomas have been associated with metastases and high mortality rate.
We reviewed the literature in the context of our report of a 68-year-old woman who had a morpheaform plaque of the upper lip of 15 years duration, extending into the left naso-genal groove, which histologically also showed marked stromal fibrosis. Three years after excision, there were no signs of recurrence or metastases.
This patient is unusual in clinical and histologic pattern, as a morpheaform appearance has only been described previously in only one sebaceous carcinoma. In addition, no metastatic disease 15 years after tumor onset is a fortunate and remarkable feature.
皮脂腺癌是一种罕见的、侵袭性的恶性肿瘤，起源于皮脂腺上皮。它可发生于眼内或眼外部位，通常表现为直径达8厘米的溃疡或非溃疡囊性结节。大量眼外皮脂腺癌与转移及高死亡率相关。
我们结合对一名68岁女性的报告回顾了文献，该女性上唇有一持续15年的硬斑病样斑块，延伸至左鼻唇沟，组织学检查也显示有明显的间质纤维化。切除三年后，无复发或转移迹象。
该患者在临床和组织学表现上均不寻常，因为硬斑病样外观此前仅在一例皮脂腺癌中被描述过。此外，肿瘤发生15年后无转移性疾病是一个幸运且显著的特征。
