Lacroix J S, Ricchetti Coignard A
Service d'oto-rhino-laryngologie et de chirurgie cervico-faciale, Unité de rhinologie-olfactologie, HUG, Genève.
Rev Med Suisse. 2005 Oct 19;1(37):2392-5.
The nasal mucosa is one of the anatomical region which have the highest density of sensory innervation. The function of this sensory innervation is probably linked to the protection of the lower airways against inhalation of airborne particles and potentially harmful substances. Chronic rhinosinusitis (CRS) is associated with nasal obstruction, rhinorrhea, loss of sense of smell and facial pain or headaches. When allergy or specific hyperreactivity, infection, systemic or genetic deseases have been excluded, the diagnosis of non specific hyperreactivity or neurogenic inflammation is proposed. Sensory neuropeptides released by sensory nerves endings have powerful proinflammatory effects. The best treatment yet available include nasal lavages and the local application of topical corticosteroid spray.
鼻黏膜是感觉神经支配密度最高的解剖区域之一。这种感觉神经支配的功能可能与保护下呼吸道免受空气中颗粒和潜在有害物质的吸入有关。慢性鼻窦炎（CRS）与鼻塞、流涕、嗅觉丧失以及面部疼痛或头痛有关。当排除过敏或特异性高反应性、感染、全身性或遗传性疾病后，可考虑诊断为非特异性高反应性或神经源性炎症。感觉神经末梢释放的感觉神经肽具有强大的促炎作用。目前可用的最佳治疗方法包括鼻腔灌洗和局部应用局部皮质类固醇喷雾剂。
