Grose C, Henle W, Henle G, Feorino P M
N Engl J Med. 1975 Feb 20;292(8):392-5. doi: 10.1056/NEJM197502202920804.
Infectious mononucleosis has been associated with Guillain--Barré syndrome, Bell's palsy, meningoencephalitis and transverse myelitis. Since it is not known that many children with infectious mononucleosis do not develop heterophil antibodies, we looked for evidence of current or recent Epstein-Barr virus infection in young patients with these neurologic diseases by using serodiagnostic procedures for detection and titration of antibodies to various antigens related to Epstein-Barr virus. Seven of 24 cases with Guillain-Barre syndrome and three of 16 with facial palsy were definitely associated with primary infection with Epstein-Barr virus as were two cases each of the other two neurologic diseases. Only one of these patients had obvious clinical infectious mononucleosis, and only a few demonstrated heterophil agglutinins. It is evident that the virus must be considered in the diagnosis of various acute neurologic diseases affecting children and young adults, even in the absence of heterophil-antibody response or other signs of infectious mononucleosis.
传染性单核细胞增多症与吉兰 - 巴雷综合征、贝尔麻痹、脑膜脑炎和横贯性脊髓炎有关。由于许多患传染性单核细胞增多症的儿童并不产生嗜异性抗体，我们通过使用血清诊断程序来检测和滴定与爱泼斯坦 - 巴尔病毒相关的各种抗原的抗体，以寻找这些神经系统疾病的年轻患者中当前或近期爱泼斯坦 - 巴尔病毒感染的证据。24例吉兰 - 巴雷综合征患者中有7例，16例面神经麻痹患者中有3例肯定与爱泼斯坦 - 巴尔病毒的原发性感染有关，另外两种神经系统疾病各有2例也是如此。这些患者中只有1例有明显的临床传染性单核细胞增多症，只有少数人表现出嗜异性凝集素。很明显，即使在没有嗜异性抗体反应或其他传染性单核细胞增多症迹象的情况下，在诊断影响儿童和年轻人的各种急性神经系统疾病时也必须考虑到该病毒。
