Shafiq Kamran, Hassan Ahamad, Davies Mervyn H, Jones Rebecca L
City Hospitals Sunderland, Sunderland, UK.
Department of Neurology, Leeds General Infirmary, Leeds, UK.
Frontline Gastroenterol. 2011 Oct;2(4):234-236. doi: 10.1136/fg.2010.003467. Epub 2011 Jul 6.
Epstein-Barr virus (EBV) infection presenting as encephalitis in seronegative adults in the context of solid organ transplantation is rarely reported. EBV seroconversion illnesses in the adult population after organ transplantation are quite uncommon. This report describes a case of encephalitis due to EBV infection after liver transplantation in an adult patient. The patient was seronegative for EBV pretransplant. She showed persistent viral replication indicated by high levels of EBV DNA in the serum, which raised concerns for future development of post-transplant lymphoproliferative disorder. The report discusses the management of such patients, awareness of EBV infection and earlier diagnosis by use of EBV PCR in adult immunocompromised individuals where infection may cause particular problems.
在实体器官移植背景下，血清学阴性的成年人中表现为脑炎的爱泼斯坦-巴尔病毒（EBV）感染鲜有报道。器官移植后成年人群中的EBV血清学转换疾病相当罕见。本报告描述了一例成年患者肝移植后因EBV感染导致脑炎的病例。该患者移植前EBV血清学阴性。她的血清中EBV DNA水平很高，表明病毒持续复制，这引发了对移植后淋巴细胞增殖性疾病未来发展的担忧。本报告讨论了此类患者的管理、对EBV感染的认识以及在成年免疫功能低下个体中通过使用EBV聚合酶链反应（PCR）进行早期诊断，因为在这些个体中感染可能会引发特殊问题。
