Haslinger B, Erhard P, Dresel C, Castrop F, Roettinger M, Ceballos-Baumann A O
Neurologische Klinik, TU-München, Munich, Germany.
Neurology. 2005 Nov 22;65(10):1562-9. doi: 10.1212/01.wnl.0000184478.59063.db.
To study with fMRI the pattern of sensorimotor activation in patients with spasmodic dysphonia (laryngeal dystonia) compared to healthy controls.
The authors performed fMRI measurements during vocal motor tasks in 12 patients with laryngeal dystonia and compared them with those of 12 healthy volunteers. Patients were scanned before (pre) and after (post) treatment with local injections of botulinum toxin (BTX). They examined two different motor tasks: simple vocalization inducing dystonia and whispering without appearance of dystonic symptoms. To avoid movement artifacts with oral motor tasks, the authors used a silent event-related fMRI approach involving noncontinuous sampling with no data acquisition during task performance.
They found reduced activation of primary sensorimotor as well as of premotor and sensory association cortices during vocalization in patients with laryngeal dystonia pre-BTX. This was partly observed also during the asymptomatic whispering task. BTX treatment did not result in reversal of reduced cortical activation.
fMRI signal is reduced in sensorimotor cortices associated with movement of the affected body part in laryngeal dystonia, supporting a dystonic basis for this voice disorder.
通过功能磁共振成像（fMRI）研究痉挛性发声障碍（喉肌张力障碍）患者与健康对照者感觉运动激活模式。
作者在12例喉肌张力障碍患者进行发声运动任务期间进行了fMRI测量，并将其与12名健康志愿者的测量结果进行比较。患者在局部注射肉毒杆菌毒素（BTX）治疗前（治疗前）和治疗后（治疗后）进行扫描。他们检查了两种不同的运动任务：诱发肌张力障碍的简单发声和无肌张力障碍症状出现的耳语。为避免口腔运动任务产生的运动伪影，作者采用了一种与事件相关的无声fMRI方法，该方法涉及非连续采样，在任务执行期间不进行数据采集。
他们发现，BTX治疗前，喉肌张力障碍患者发声时初级感觉运动皮层以及运动前区和感觉联合皮层的激活减少。在无症状的耳语任务期间也部分观察到了这一现象。BTX治疗并未导致皮层激活减少的情况得到逆转。
在喉肌张力障碍中，与受影响身体部位运动相关的感觉运动皮层中fMRI信号降低，支持了这种声音障碍的肌张力障碍基础。
