Kumari Meena, Marmot Michael
Department of Epidemiology and Public Health, International Centre for Health and Society, London, UK.
Neurology. 2005 Nov 22;65(10):1597-603. doi: 10.1212/01.wnl.0000184521.80820.e4.
To compare cognitive performance in those with diabetes, impaired glucose tolerance, and normoglycemia in a middle-aged cohort.
The authors analyzed data from a prospective occupational cohort study begun in 1985-1988 (baseline). Diabetes was classified from oral glucose tolerance tests that were performed in 1992-1993 (phase 3) and 1997-1999 (phase 5) and self reported diagnosis of diabetes from questionnaire at baseline, 1989 (phase 2), phase 3, 1995 (phase 4), and phase 5 of the study. A battery of cognitive tests (memory, Alice Heim 4 [AH 4], Mill Hill vocabulary test, phonemic fluency, and categorical fluency) were measured at phase 5 in 4,020 men and 1,627 women with a mean age of 56 and free of symptoms of stroke.
At phase 5, a total of 208 (5%) men and 101 (6%) women had diabetes while 405 (10%) men and 192 (12%) women had impaired glucose tolerance. Those with diabetes were at increased risk of poor performance in AH 4 compared to those without (men: OR, 2.45; 95% CI, 1.77 to 3.38; women: OR, 1.83; 95% CI, 1.09 to 3.08). These effects were independent of age, social position, vascular problems, and health-related behaviors. Impaired glucose tolerance was not related to any measure of cognition.
Type 2 diabetes is associated with poor performance in some aspects of cognition in middle-aged men and women.
比较中年队列中糖尿病患者、糖耐量受损者和血糖正常者的认知表现。
作者分析了一项始于1985 - 1988年（基线期）的前瞻性职业队列研究的数据。糖尿病通过1992 - 1993年（第3阶段）和1997 - 1999年（第5阶段）进行的口服葡萄糖耐量试验以及研究基线期（1989年，第2阶段）、第3阶段（1995年，第4阶段）和第5阶段问卷调查中的糖尿病自我报告诊断进行分类。在第5阶段，对4020名男性和1627名女性进行了一系列认知测试（记忆、爱丽丝·海姆4[AH4]、米尔希尔词汇测试、音素流畅性和类别流畅性），这些人平均年龄为56岁，无中风症状。
在第5阶段，共有208名（5%）男性和101名（6%）女性患有糖尿病，而405名（10%）男性和192名（12%）女性糖耐量受损。与未患糖尿病者相比，糖尿病患者在AH4测试中表现不佳的风险增加（男性：比值比[OR]，2.45；95%置信区间[CI]，1.77至3.38；女性：OR，1.83；95%CI，1.09至3.08）。这些影响独立于年龄、社会地位、血管问题和健康相关行为。糖耐量受损与任何认知指标均无关联。
2型糖尿病与中年男性和女性某些认知方面的表现不佳有关。
