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存在强烈的转换-颠换和G+C含量偏差时核苷酸替换数目的估计

Estimation of the number of nucleotide substitutions when there are strong transition-transversion and G+C-content biases.

作者信息

Tamura K

机构信息

Department of Biology, Tokyo Metropolitan University.

出版信息

Mol Biol Evol. 1992 Jul;9(4):678-87. doi: 10.1093/oxfordjournals.molbev.a040752.

DOI:10.1093/oxfordjournals.molbev.a040752
PMID:1630306
Abstract

A simple mathematical method is developed to estimate the number of nucleotide substitutions per site between two DNA sequences, by extending Kimura's (1980) two-parameter method to the case where a G+C-content bias exists. This method will be useful when there are strong transition-transversion and G+C-content biases, as in the case of Drosophila mitochondrial DNA.

摘要

通过将木村（1980年）的双参数方法扩展到存在G+C含量偏差的情况，开发了一种简单的数学方法来估计两个DNA序列之间每个位点的核苷酸替换数。当存在强烈的转换-颠换和G+C含量偏差时，如在果蝇线粒体DNA的情况下，这种方法将很有用。

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