Bruce Adrian
Clinical Vision Research Australia, Victorian College of Optometry, Corner Cardigan and Keppel Sts, Carlton 3053, Vic., Australia.
Cont Lens Anterior Eye. 2003 Dec;26(4):189-96. doi: 10.1016/j.clae.2003.09.001.
Despite global standardisation in measurement of oxygen transmissibility (Dk/t), in our clinic we continue to see limbal vasculature changes in patients wearing some disposable lenses. The use of central Dk/t as a simple designator of a contact lens oxygen performance has clearly failed, it being acknowledged as often unrelated to the oxygen performance of the lens periphery. This study investigates a new criterion for contact lens oxygen transmissibility, the local Dk/t.
The study measured 20 spherical disposable lens brands (power range: -15.00 to +8.00 D) and 8 toric lens brands (power range: -8.00 to +4.00 D sphere, with a -1.00 D/-1.25 D x 180). An electro-mechanical gauge (Heidenhain, Germany) was used to measure lens thickness (t) at different positions on the lens. Oxygen permeability (Dk) of each lens material was calculated from the equation Dk =1.67 e (0.0397 x water content) of Morgan and Efron [Contact Lens Anterior Eye 21 (1998) 3] who used ISO/ANSI standard methodologies. The local Dk/t value was calculated from the point of maximum thickness on the lens and compared to the criterion of 12 Fatt units set by Benjamin [Int. Contact Lens Clin. 23 (1996) 188], to provide corneal oxygenation greater than or comparable to that available in the normal closed eye.
All lens types with a water content over 65% had a local Dk/t of 12 Fatt units or more for most or all lens powers: CIBAVision FocusDailies, Bausch & Lomb Soflens66, CooperVision Actifresh400, and CIBAVision PrecisionUV. In addition, some lenses in the 55-62% water content range had some lens powers with a local Dk/t in excess of 12: CooperVision Proclear, Johnson & Johnson Acuvue 1 and CIBAVision Focus 2 week. None of the disposable toric lenses had a minimum Dk/t of 12 or more. The silicone-hydrogels, Bausch & Lomb PureVision and CIBAVision Focus Night&Day, comfortably exceeded Dk/t of 50 for all lens powers.
Some current disposable soft lenses have local Dk/t values below physiological requirements. Contact lens manufacturers and international standards organisations should consider introducing the labelling of local Dk/t values on lens packaging so that clinicians can make informed prescribing decisions.
尽管在氧气透过率(Dk/t)测量方面实现了全球标准化,但在我们的诊所中,仍不断看到佩戴某些一次性隐形眼镜的患者出现角膜缘血管变化。将中心Dk/t用作隐形眼镜氧气性能的简单指标显然是失败的,因为人们公认它通常与镜片周边的氧气性能无关。本研究调查了一种用于隐形眼镜氧气透过率的新标准,即局部Dk/t。
该研究测量了20个球形一次性镜片品牌(屈光度范围:-15.00至+8.00 D)和8个 toric镜片品牌(屈光度范围:-8.00至+4.00 D球镜,柱镜-1.00 D/-1.25 D×180)。使用电子机械测量仪(德国海德汉)测量镜片不同位置的厚度(t)。根据Morgan和Efron [《隐形眼镜与眼前节》21 (1998) 3] 的公式Dk =1.67 e (0.0397×含水量) 计算每种镜片材料的氧气透过率(Dk),他们采用了ISO/ANSI标准方法。从镜片最厚点计算局部Dk/t值,并与Benjamin [《国际隐形眼镜临床》23 (1996) 188] 设定的12 Fatt单位标准进行比较,以提供大于或等同于正常闭眼时角膜的氧合作用。
对于大多数或所有镜片屈光度,所有含水量超过65%的镜片类型的局部Dk/t为12 Fatt单位或更高:博士伦清朗日抛、博士伦纯视66、酷柏视康清新水润400和博士伦精准UV。此外,一些含水量在55 - 62%范围内的镜片,部分屈光度的局部Dk/t超过12:酷柏视康倍明视、强生安视优1日抛和博士伦焦点2周抛。所有一次性toric镜片的最低Dk/t均未达到12或更高。硅水凝胶镜片博士伦纯视和博士伦日夜型,所有屈光度的Dk/t轻松超过50。
一些当前的一次性软性隐形眼镜的局部Dk/t值低于生理需求。隐形眼镜制造商和国际标准组织应考虑在镜片包装上标注局部Dk/t值,以便临床医生能够做出明智的处方决策。