Ianosi-Irimie Monica, Vu Hop V, Whitbred Joy M, Pridjian Candice A, Nadig J D, Williams Marian Y, Wrenn Dené C, Pridjian Gabriella, Puschett Jules B
Department of Medicine, Tulane University School of Medicine, New Orleans, Louisiana, USA.
Clin Exp Hypertens. 2005 Nov;27(8):605-17. doi: 10.1080/10641960500298608.
Preeclampsia/eclampsia is a disorder of human pregnancy that continues to exact significant maternal morbidity and mortality and fetal wastage. Therapy of these disorders has not changed in over 50 years and there are no proven preventive measures. We describe a model of the development of a syndrome in the pregnant rat that resembles preeclampsia, which results from the imposition of excessive volume expansion early in gestation. We administered desoxycorticosterone acetate (DOCA) to pregnant animals whose drinking water had been replaced with saline. We compared the results obtained in these animals with those resulting from the study of control, virgin animals, virgin animals receiving DOCA and saline, and normal pregnant (NP) animals. The virgin animals given DOCA and saline did not become hypertensive. The experimental paradigm in the DOCA plus saline pregnant (PDS) animals provides many of the phenotypic characteristics of the human disorder including the development of hypertension, proteinuria, and intrauterine growth restriction. In addition, the mean blood nitrite/nitrate concentration was reduced in the PDS rats compared with their NP counterparts. We propose that this model may prove to be useful in the study of the human condition.
子痫前期/子痫是一种妊娠期疾病，持续导致严重的孕产妇发病和死亡以及胎儿流产。这些疾病的治疗在50多年来一直没有改变，也没有经过验证的预防措施。我们描述了一种孕鼠综合征的发展模型，该模型类似于子痫前期，它是由妊娠早期过度的容量扩张引起的。我们给饮用水被盐水替代的怀孕动物注射醋酸脱氧皮质酮（DOCA）。我们将这些动物的结果与对照、未孕动物、接受DOCA和盐水的未孕动物以及正常怀孕（NP）动物的研究结果进行了比较。给予DOCA和盐水的未孕动物没有出现高血压。DOCA加盐水怀孕（PDS）动物的实验范式呈现出许多人类疾病的表型特征，包括高血压、蛋白尿和宫内生长受限的发展。此外，与NP大鼠相比，PDS大鼠的平均血中亚硝酸盐/硝酸盐浓度降低。我们认为这个模型可能在人类疾病的研究中被证明是有用的。
