Inoue S, Koshiro K, Yoshida Y, De Munck J, Nagakane K, Suzuki K, Sano H, Van Meerbeek B
Division for General Dentistry, Center for Dental Clinics, Hokkaido University Hospital, Kita 13 Nishi 7, Kita-ku, Sapporo 060-8586, Japan.
J Dent Res. 2005 Dec;84(12):1160-4. doi: 10.1177/154405910508401213.
Functional monomers chemically interact with hydroxyapatite that remains within submicron hybrid layers produced by mild self-etch adhesives. The functional monomer 10-MDP interacts most intensively with hydroxyapatite, and its calcium salt appeared most hydrolytically stable, as compared with 4-MET and phenyl-P. We investigated the hypothesis that additional chemical interaction of self-etch adhesives improves bond stability. The micro-tensile bond strength (muTBS) of the 10-MDP-based adhesive did not decrease significantly after 100,000 cycles, but did after 50,000 and 30,000 cycles, respectively, for the 4-MET-based and the phenyl-P-based adhesives. Likewise, the interfacial ultrastructure was unchanged after 100,000 thermocycles for the 10-MDP-based adhesive, while that of both the 4-MET- and phenyl-P-based adhesives contained voids and less-defined collagen. The findings of this study support the concept that long-term durability of adhesive-dentin bonds depends on the chemical bonding potential of the functional monomer.
功能单体与轻度自酸蚀粘结剂产生的亚微米混合层中残留的羟基磷灰石发生化学相互作用。与4-MET和苯基-P相比，功能单体10-MDP与羟基磷灰石的相互作用最为强烈，其钙盐的水解稳定性也最高。我们研究了自酸蚀粘结剂的额外化学相互作用可提高粘结稳定性这一假设。基于10-MDP的粘结剂在100,000次循环后微拉伸粘结强度（muTBS）没有显著降低，但基于4-MET和苯基-P的粘结剂分别在50,000次和30,000次循环后微拉伸粘结强度降低。同样，基于10-MDP的粘结剂在100,000次热循环后界面超微结构未发生变化，而基于4-MET和苯基-P的粘结剂的界面超微结构均含有空隙且胶原界定不清。本研究结果支持粘结剂与牙本质粘结的长期耐久性取决于功能单体化学键合潜力这一概念。
