不对称Biginelli反应中具有立体选择性诱导的多种方法。

Diverse Methods with Stereoselective Induction in the Asymmetric Biginelli Reaction.

作者信息

Díaz-Fernández Marcos, Algarra Manuel, Calvo-Losada Saturnino, Quirante José-Joaquín, Sarabia Francisco, Pino-González María-Soledad

机构信息

Department of Organic Chemistry, Faculty of Sciences, University of Málaga, 29071 Málaga, Spain.

Department of Physical Chemistry, Faculty of Sciences, University of Málaga, 29071 Málaga, Spain.

出版信息

Molecules. 2024 Aug 15;29(16):3864. doi: 10.3390/molecules29163864.

The relevance of the asymmetric Biginelli reaction (ABR) has been increased in this century, due to the pharmacological application of its products. This review focuses predominantly on articles published in the period from 2015 to 2024 on asymmetric synthetic advances in the formation of dihydropyrimidinones (DHPMs), dihydropyrimidinethiones (DHPMTs), and related compounds. The relevant bibliography on general processes in the Biginelli reaction and some methods of separation of isomers have also been referenced.