Kostova Irena
Department of Chemistry, Faculty of Pharmacy, Medical University, 2 Dunav St., Sofia 1000, Bulgaria.
Curr Med Chem Anticancer Agents. 2005 Nov;5(6):591-602. doi: 10.2174/156801105774574694.
The application of inorganic chemistry to medicine is a rapidly developing field, and novel therapeutic and diagnostic metals and metal complexes are now having an impact on medical practice. Advances in biocoordination chemistry are crucial for improving the design of compounds to reduce toxic side effects and understand their mechanisms of action. A lot of metal-based drugs are widely used in the treatment of cancer. The clinical success of cisplatin and other platinum complexes is limited by significant side effects acquired or intrinsic resistance. Therefore, much attention has focused on designing new coordination compounds with improved pharmacological properties and a broader range of antitumor activity. Strategies for developing new anticancer agents include the incorporation of carrier groups that can target tumor cells with high specificity. Also of interest is to develop complexes that bind to DNA in a fundamentally different manner than cisplatin, in an attempt to overcome the resistance pathways that have evolved to eliminate the drug. This review focuses on recent advances in developing lanthanide anticancer agents with an emphasis on lanthanide coordination complexes. These complexes may provide a broader spectrum of antitumor activity. They were compared with classical platinum anticancer drugs. Lanthanides are also of interest because of their therapeutic radioisotopes. The dominant pharmacological applications of lanthanides are as agents in radioimmunotherapy and photodynamic therapy.
无机化学在医学上的应用是一个快速发展的领域，新型治疗和诊断用金属及金属配合物正影响着医疗实践。生物配位化学的进展对于改进化合物设计以减少毒副作用并了解其作用机制至关重要。许多金属基药物被广泛用于癌症治疗。顺铂和其他铂配合物的临床成功受到获得性或内在耐药性以及显著副作用的限制。因此，人们将大量注意力集中在设计具有改善药理特性和更广泛抗肿瘤活性的新型配位化合物上。开发新型抗癌药物的策略包括引入能够高度特异性靶向肿瘤细胞的载体基团。同样令人感兴趣的是开发与顺铂以根本不同方式结合DNA的配合物，以试图克服已进化出的消除药物的耐药途径。本综述着重介绍镧系元素抗癌药物的最新进展，重点是镧系元素配位配合物。这些配合物可能具有更广泛的抗肿瘤活性谱。将它们与经典铂类抗癌药物进行了比较。镧系元素因其治疗性放射性同位素也备受关注。镧系元素主要的药理学应用是作为放射免疫治疗和光动力治疗的药物。
