Department of Chemistry, Punjabi University, Patiala, Punjab, India.
Department of Chemistry, Patel Memorial National College, Punjab, India.
J Trace Elem Med Biol. 2023 Dec;80:127277. doi: 10.1016/j.jtemb.2023.127277. Epub 2023 Aug 2.
Developing new therapeutic and diagnostic metals and metal complexes is a stunning example of how inorganic chemistry is rapidly becoming an essential part of modern medicine. More study of bio-coordination chemistry is needed to improve the design of compounds with fewer harmful side effects. Metal-containing drugs are widely utilized in the treatment of cancer. Platinum complexes are effective against some cancers, but new coordination compounds are being created with improved pharmacological properties and a broader spectrum of anticancer action. The coordination complexes of the 15 lanthanides or rare earth elements in the periodic table are crucial for diagnosing and treating cancer. Understanding and treating cancer requires the detection of binding lanthanide (III) ions or complexes to DNA and breaking DNA by these complexes. Current advances in lanthanide-based coordination complexes as anticancer treatments over the past five years are discussed in this study.
开发新的治疗和诊断用金属及金属配合物是无机化学如何迅速成为现代医学重要组成部分的一个惊人范例。为了改进设计副作用更小的化合物,需要更多的生物配位化学研究。含金属药物广泛用于癌症治疗。铂配合物对某些癌症有效,但新的配位化合物正在被开发出来,具有改善的药理学性质和更广泛的抗癌作用。镧系元素周期表中的 15 个镧系元素或稀土元素的配位化合物对于癌症的诊断和治疗至关重要。理解和治疗癌症需要检测镧(III)离子或配合物与 DNA 的结合,并通过这些配合物破坏 DNA。本研究讨论了过去五年中基于镧系元素的配位配合物作为抗癌治疗的最新进展。