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纳米羟基磷灰石在医学中的应用——一篇叙述性综述

Application of Nanohydroxyapatite in Medicine-A Narrative Review.

作者信息

Lubojański Adam, Zakrzewski Wojciech, Samól Kinga, Bieszczad-Czaja Martyna, Świtała Mateusz, Wiglusz Rafał, Watras Adam, Mielan Bartosz, Dobrzyński Maciej

机构信息

Department of Pediatric Dentistry and Preclinical Dentistry, Wroclaw Medical University, Krakowska 26, 50-425 Wrocław, Poland.

Pre-Clinical Research Centre, Wroclaw Medical University, Bujwida 44, 50-345 Wroclaw, Poland.

出版信息

Molecules. 2024 Nov 28;29(23):5628. doi: 10.3390/molecules29235628.

DOI:10.3390/molecules29235628
PMID:39683785
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11643452/
Abstract

This review is an extensive collection of the latest literature describing the current knowledge about nanohydroxyapatite in a comprehensive way. These are hydroxyapatite particles with a size below 100 nm. Due to their size, the surface area to mass ratio of the particles increases. They are widely used in medicine due to their high potential in regenerative medicine, as a carrier of various substances, e.g., in targeted therapy. The aim of this article is to present the biological and physicochemical properties as well as the use of nanohydroxyapatite in modern medicine. Due to the potential of nanohydroxyapatite in medicine, further research is needed.

摘要

本综述广泛收集了最新文献，全面描述了目前关于纳米羟基磷灰石的知识。这些是尺寸小于100纳米的羟基磷灰石颗粒。由于其尺寸，颗粒的表面积与质量之比增加。由于它们在再生医学中具有很高的潜力，作为各种物质的载体，例如在靶向治疗中，它们在医学中被广泛应用。本文的目的是介绍纳米羟基磷灰石的生物学和物理化学性质以及在现代医学中的应用。鉴于纳米羟基磷灰石在医学中的潜力，还需要进一步的研究。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/036f/11643452/0a9974f6f889/molecules-29-05628-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/036f/11643452/08f1e77bd25c/molecules-29-05628-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/036f/11643452/f2adcfd1ae77/molecules-29-05628-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/036f/11643452/54519ffe9642/molecules-29-05628-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/036f/11643452/eeb2b5deab20/molecules-29-05628-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/036f/11643452/0a9974f6f889/molecules-29-05628-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/036f/11643452/08f1e77bd25c/molecules-29-05628-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/036f/11643452/f2adcfd1ae77/molecules-29-05628-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/036f/11643452/54519ffe9642/molecules-29-05628-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/036f/11643452/eeb2b5deab20/molecules-29-05628-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/036f/11643452/0a9974f6f889/molecules-29-05628-g001.jpg

相似文献

[1]
Application of Nanohydroxyapatite in Medicine-A Narrative Review.

Molecules. 2024-11-28

[2]
Nanohydroxyapatite as a Biomaterial for Peripheral Nerve Regeneration after Mechanical Damage-In Vitro Study.

Int J Mol Sci. 2021-4-24

[3]
[Development of nanohydroxyapatite composites as bone grafting materials].

Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2008-10

[4]
A short view on nanohydroxyapatite as coating of dental implants.

Biomed Pharmacother. 2018-6-7

[5]
Radiolabelled nanohydroxyapatite with 99mTc: perspectives to nanoradiopharmaceuticals construction.

Artif Cells Nanomed Biotechnol. 2013-4-16

[6]
Coating nanothickness degradable films on nanocrystalline hydroxyapatite particles to improve the bonding strength between nanohydroxyapatite and degradable polymer matrix.

J Biomed Mater Res A. 2007-8

[7]
Nanohydroxyapatite as the key factor in bone regeneration.

Wiad Lek. 2025

[8]
Nanoscale hydroxyapatite particles for bone tissue engineering.

Acta Biomater. 2011-4-1

[9]
Biocomposites of nanohydroxyapatite with collagen and poly(vinyl alcohol).

Colloids Surf B Biointerfaces. 2006-3-1

[10]
Development and Optimization of the Novel Fabrication Method of Highly Macroporous Chitosan/Agarose/Nanohydroxyapatite Bone Scaffold for Potential Regenerative Medicine Applications.

Biomolecules. 2019-9-1

引用本文的文献

[1]
Novel Applications of Natural Biomaterials in Dentistry-Properties, Uses, and Development Perspectives.

Materials (Basel). 2025-5-5

本文引用的文献

[1]
Evaluating various properties of nanohydroxyapatite synthesized from eggshells and dual-doped with Si and Zn: An in vitro study.

Heliyon. 2024-8-8

[2]
Enhancing orthodontic treatment control with fish scale-derived hydroxyapatite nanoparticles: Insights from an animal model study.

Saudi Dent J. 2024-8

[3]
Bioglass and nano bioglass: A next-generation biomaterial for therapeutic and regenerative medicine applications.

Int J Biol Macromol. 2024-10

[4]
The Effects of a Novel Nanohydroxyapatite Gel and Er: YAG Laser Treatment on Dentin Hypersensitivity.

Materials (Basel). 2023-9-30

[5]
Nanohydroxyapatite in dentistry: A comprehensive review.

Saudi Dent J. 2023-9

[6]
Green synthesis of nanohydroxyapatite trough Elaeagnus angustifolia L. extract and evaluating its anti-tumor properties in MCF7 breast cancer cell line.

BMC Complement Med Ther. 2023-9-26

[7]
Effect of Commercially Available Nano-Hydroxyapatite Containing Desensitizing Toothpaste and Mouthwash on Dentinal Tubular Occlusion: A SEM Analysis.

J Pharm Bioallied Sci. 2023-7

[8]
Imatinib-Functionalized Galactose Hydrogels Loaded with Nanohydroxyapatite as a Drug Delivery System for Osteosarcoma: In Vitro Studies.

ACS Omega. 2023-5-9

[9]
Biodegradable manganese-doped hydroxyapatite antitumor adjuvant as a promising photo-therapeutic for cancer treatment.

Front Mol Biosci. 2022-11-23

[10]
Calcium Phosphate-Based Biomaterials for Bone Repair.

J Funct Biomater. 2022-10-14

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