Butte Nancy F, Comuzzie Anthony G, Cole Shelley A, Mehta Nitesh R, Cai Guowen, Tejero Maria, Bastarrachea Raul, Smith E O'Brian
Department of Pediatrics, USDA/ARS Children's Nutrition Research Center, Baylor College of Medicine, Houston, TX 77030, USA.
Pediatr Res. 2005 Dec;58(6):1243-8. doi: 10.1203/01.pdr.0000185272.46705.18.
Childhood obesity is associated with a constellation of metabolic derangements including glucose intolerance, hypertension, and dyslipidemia, referred to as metabolic syndrome. The purpose of this study was to investigate genetic and environmental factors contributing to the metabolic syndrome in Hispanic children. Metabolic syndrome, defined as having three or more metabolic risk components, was determined in 1030 Hispanic children, ages 4-19 y, from 319 families enrolled in the VIVA LA FAMILIA study. Anthropometry, body composition by dual energy x-ray absorptiometry, clinical signs, and serum biochemistries were measured using standard techniques. Risk factor analysis and quantitative genetic analysis were performed. Of the overweight children, 20%, or 28% if abnormal liver function is included in the definition, presented with the metabolic syndrome. Odds ratios for the metabolic syndrome were significantly increased by body mass index z-score and fasting serum insulin; independent effects of sex, age, puberty, and body composition were not seen. Heritabilities +/- SE for waist circumference, triglycerides (TG), HDL, systolic blood pressure (SBP), glucose, and alanine aminotransferase (ALT) were highly significant. Pleiotropy (a common set of genes affecting two traits) detected between SBP and waist circumference, SBP and glucose, HDL and waist circumference, ALT and waist circumference, and TG and ALT may underlie the clustering of the components of the metabolic syndrome. Significant heritabilities and pleiotropy seen for the components of the metabolic syndrome indicate a strong genetic contribution to the metabolic syndrome in overweight Hispanic children.
儿童肥胖与一系列代谢紊乱相关，包括葡萄糖耐量异常、高血压和血脂异常，即代谢综合征。本研究的目的是调查导致西班牙裔儿童代谢综合征的遗传和环境因素。代谢综合征定义为具有三个或更多代谢风险成分，在参与“VIVA LA FAMILIA研究”的319个家庭的1030名4至19岁西班牙裔儿童中进行了测定。使用标准技术测量人体测量学指标、通过双能X线吸收法测定身体成分、临床体征和血清生物化学指标。进行了风险因素分析和定量遗传分析。在超重儿童中，20%（如果将肝功能异常纳入定义则为28%）患有代谢综合征。代谢综合征的比值比因体重指数z评分和空腹血清胰岛素而显著升高；未观察到性别、年龄、青春期和身体成分的独立影响。腰围、甘油三酯（TG）、高密度脂蛋白（HDL）、收缩压（SBP）、葡萄糖和丙氨酸转氨酶（ALT）的遗传力±标准误非常显著。收缩压与腰围、收缩压与葡萄糖、高密度脂蛋白与腰围、谷丙转氨酶与腰围以及甘油三酯与谷丙转氨酶之间检测到的多效性（一组共同影响两个性状的基因）可能是代谢综合征各成分聚集的基础。代谢综合征各成分显著的遗传力和多效性表明超重西班牙裔儿童的代谢综合征有很强的遗传因素。
