Hodges A N H, Lynn B M, Koehle M S, McKenzie D C
School of Human Kinetics, University of British Columbia, Vancouver, Canada.
Br J Sports Med. 2005 Dec;39(12):917-20. doi: 10.1136/bjsm.2005.017806.
To determine the effect of prophylactic treatment with an inhaled bronchodilator and anti-inflammatory on arterial saturation (SaO2) in trained non-asthmatic male athletes with exercise induced arterial hypoxaemia (EIAH).
Nine male athletes (mean (SD) age 26.3 (6.7) years, height 182.6 (7.9) cm, weight 79.3 (10.5) kg, VO2MAX 62.3 (6.3) ml/kg/min, SaO2MIN 92.5 (1.1)%) with no history of asthma were tested in two experimental conditions. A combination of a therapeutic dose of salbutamol and fluticasone or an inert placebo was administered in a randomised crossover design for seven days before maximal cycling exercise. Oxygen consumption (VO2), ventilation (VE), heart rate (HR), power output, and SaO2 were monitored during the exercise tests.
There were no significant differences between the drug (D) and placebo (P) conditions for minimal SaO2 (D = 93.6 (1.4), P = 93.0 (1.1)%; p = 0.93) VO2MAX (D = 61.5 (7.2), P = 61.9 (6.3) ml/kg/min; p = 0.91), peak power (D = 444.4 (48.3), P = 449.4 (43.9) W; p = 0.90), peak VE (D = 147.8 (19.1), P = 149.2 (15.5) litres/min; p = 0.82), or peak heart rate (D = 182.3 (10.0), P = 180.8 (5.5) beats/min; p = 0.76).
A therapeutic dose of salbutamol and fluticasone did not attenuate EIAH during maximal cycling in a group of trained male non-asthmatic athletes.
确定吸入性支气管扩张剂和抗炎药物预防性治疗对患有运动性动脉血氧不足（EIAH）的受过训练的非哮喘男性运动员动脉血氧饱和度（SaO2）的影响。
对9名无哮喘病史的男性运动员（平均（标准差）年龄26.3（6.7）岁，身高182.6（7.9）厘米，体重79.3（10.5）千克，最大摄氧量62.3（6.3）毫升/千克/分钟，最低SaO2 92.5（1.1）%）在两种实验条件下进行测试。在进行最大强度自行车运动前7天，采用随机交叉设计给予治疗剂量的沙丁胺醇和氟替卡松组合或惰性安慰剂。在运动测试期间监测耗氧量（VO2）、通气量（VE）、心率（HR）、功率输出和SaO2。
在最低SaO2（药物组（D）=93.6（1.4），安慰剂组（P）=93.0（1.1）%；p = 0.93）、最大摄氧量（D = 61.5（7.2），P = 61.9（6.3）毫升/千克/分钟；p = 0.91）、峰值功率（D = 444.4（48.3），P = 449.4（43.9）瓦；p = 0.90）、峰值通气量（D = 147.8（19.1），P = 149.2（15.5）升/分钟；p = 0.82）或峰值心率（D = 182.3（10.0），P = 180.8（5.5）次/分钟；p = 0.76）方面，药物组和安慰剂组之间无显著差异。
在一组受过训练的男性非哮喘运动员进行最大强度自行车运动期间，治疗剂量的沙丁胺醇和氟替卡松并未减轻运动性动脉血氧不足。
