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用于立体定向体部放射治疗的图像引导门控系统的靶向准确性。

Targeting accuracy of an image guided gating system for stereotactic body radiotherapy.

作者信息

Tenn Stephen E, Solberg Timothy D, Medin Paul M

机构信息

Department of Radiation Oncology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.

出版信息

Phys Med Biol. 2005 Dec 7;50(23):5443-62. doi: 10.1088/0031-9155/50/23/002. Epub 2005 Nov 8.

Abstract

Recently, a commercial system capable of x-ray image guided patient positioning and respiratory gated delivery has become available. Here we describe the operational principles of this system and investigate its geometric targeting accuracy under controlled conditions. The system tracks breathing via infrared (IR) detection of reflective markers located on the patient's abdomen. Localization kilovoltage (kV) x-rays are triggered from within the gated delivery window portion of the breathing trace and after positioning, the tumour will cross the linac isocentre during gated delivery. We tested geometric accuracy of this system by localizing and delivering gated fields to a moving phantom. Effects of phantom speed, gating window location, timing errors and phantom rotations on positioning and gating accuracy were investigated. The system delivered gated fields to both a moving and static phantom with equal accuracy. The position of the gating window affects accuracy only to the extent that an asymmetric breathing motion could affect dose distribution within its boundaries. Positioning errors were found to be less then 0.5 +/- 0.2 mm for phantom rotations up to 5 degrees. We found and corrected a synchronization error caused by a faulty x-ray duration setting and detected a 60 +/- 20 ms time delay in our linear accelerator.

摘要

最近,一种能够进行X射线图像引导患者定位和呼吸门控给药的商业系统已经问世。在此,我们描述该系统的工作原理,并在可控条件下研究其几何靶向精度。该系统通过对位于患者腹部的反射标记进行红外(IR)检测来追踪呼吸。在呼吸轨迹的门控给药窗口部分内触发定位千伏(kV)X射线,定位后,肿瘤将在门控给药期间穿过直线加速器等中心。我们通过对移动体模进行定位并输送门控野来测试该系统的几何精度。研究了体模速度、门控窗口位置、时间误差和体模旋转对定位和门控精度的影响。该系统以相同的精度向移动和静态体模输送门控野。门控窗口的位置仅在不对称呼吸运动可能影响其边界内剂量分布的程度上影响精度。对于高达5度的体模旋转,发现定位误差小于0.5±0.2毫米。我们发现并纠正了由错误的X射线持续时间设置引起的同步误差,并在我们的直线加速器中检测到60±20毫秒的时间延迟。

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