老年哮喘患者中磷酸二酯酶3抑制与咳嗽
Phosphodiesterase 3 inhibition and cough in elderly asthmatics.
作者信息
Ishiura Yoshihisa, Fujimura Masaki, Nobata Kouichi, Abo Miki, Oribe Takayoshi, Myou Shigeharu, Nakamura Hiroyuki
机构信息
The Department of Internal Medicine, Toyama City Hospital, Toyama, Japan.
出版信息
Cough. 2005 Nov 24;1:11. doi: 10.1186/1745-9974-1-11.
AIMS
Cough is a common symptom of bronchial asthma, a chronic inflammatory airway disease. Recently, the therapeutic effects of selective phosphodiesterase (PDE) inhibitors have been focused on bronchial asthma. This study was designed to investigate the clinical effect of PDE 3 inhibition on cough reflex sensitivity in elderly patients with bronchial asthma.
METHODS
Effects of cilostazol, a PDE 3 inhibitor, on cough response to inhaled capsaicin were examined in 11 patients over 70 years with stable asthma in a randomized, placebo-controlled cross over study. Capsaicin cough threshold, defined as the lowest concentration of capsaicin eliciting five or more coughs, was measured as an index of airway cough reflex sensitivity.
RESULTS
The cough threshold was significantly (p < 0.05) increased after two-week treatment with cilostazol (100 mg twice a day orally) compared with placebo [48.8 (GSEM 1.4) vs. 29.2 (GSEM 1.3) muM].
CONCLUSION
These findings indicate that PDE 3 inhibition may be a novel therapeutic option for elderly patients with asthma, especially for their cough symptoms.
目的
咳嗽是支气管哮喘（一种慢性气道炎症性疾病）的常见症状。近来，选择性磷酸二酯酶（PDE）抑制剂的治疗效果已聚焦于支气管哮喘。本研究旨在探讨PDE 3抑制对老年支气管哮喘患者咳嗽反射敏感性的临床效果。
方法
在一项随机、安慰剂对照的交叉研究中，对11名70岁以上的稳定期哮喘患者，检测PDE 3抑制剂西洛他唑对吸入辣椒素后咳嗽反应的影响。辣椒素咳嗽阈值定义为引发五次或更多次咳嗽的辣椒素最低浓度，将其作为气道咳嗽反射敏感性的指标进行测量。
结果
与安慰剂相比，西洛他唑（每日口服两次，每次100毫克）治疗两周后，咳嗽阈值显著升高（p < 0.05）[48.8（GSEM 1.4）对29.2（GSEM 1.3）微摩尔]。
结论
这些发现表明，PDE 3抑制可能是老年哮喘患者的一种新的治疗选择，尤其是对其咳嗽症状。
Zotero 插件