Dzhodzhua G N, Kochiashvili D K
Georgian Med News. 2005 Oct(127):16-9.
The urine concentration of IL-6, IL-8 and nitric oxide (NO) were determined in the patients with pyelonephritis and hydronephrosis. Correlations between urine levels of IL-6 and IL-8 and amount of nitric oxide in the hydronephrosis patients were not found. However, in the patients with both acute and chronic pyelonephritis the coefficient of correlation was high, r((IL-6/NO)) = 0,94 and r((IL-8/NO)) = 0,86 for acute and r((IL-6/NO)) = 0,72 and r((IL-8/NO)) = 0,40 for chronic forms, respectively. These data suggest that secretion of NO during hydronephrosis has a compensatory character and acted on renal microvascular tone, whereas during pyelonephritis NO produced inflammatory mediators by recruiting leukocytes and has pathogenic character.
测定了肾盂肾炎和肾积水患者尿液中白细胞介素-6（IL-6）、白细胞介素-8（IL-8）和一氧化氮（NO）的浓度。未发现肾积水患者尿液中IL-6和IL-8水平与一氧化氮量之间存在相关性。然而，在急性和慢性肾盂肾炎患者中，相关性系数较高，急性肾盂肾炎患者中r（（IL-6/NO））=0.94，r（（IL-8/NO））=0.86；慢性肾盂肾炎患者中r（（IL-6/NO））=0.72，r（（IL-8/NO））=0.40。这些数据表明，肾积水期间NO的分泌具有代偿性，作用于肾微血管张力，而在肾盂肾炎期间，NO通过募集白细胞产生炎症介质，具有致病性。
