作为雌激素受体β选择性SERMs的雄烯二醇类似物。
Androstenediol analogs as ER-beta-selective SERMs.
作者信息
Blizzard Timothy A, Gude Candido, Morgan Jerry D, Chan Wanda, Birzin Elizabeth T, Mojena Marina, Tudela Consuelo, Chen Fang, Knecht Kristin, Su Qin, Kraker Bryan, Mosley Ralph T, Holmes Mark A, Sharma Nandini, Fitzgerald Paula M D, Rohrer Susan P, Hammond Milton L
机构信息
Merck Research Laboratories, PO Box 2000, Rahway NJ 07065, USA.
出版信息
Bioorg Med Chem Lett. 2006 Feb 15;16(4):834-8. doi: 10.1016/j.bmcl.2005.11.014. Epub 2005 Nov 23.
PMID:16309907
Abstract
A series of 19-substituted androstenediol derivatives was prepared. Some of the novel analogs were surprisingly potent and selective ligands for ER-beta.
摘要
制备了一系列19-取代的雄烯二醇衍生物。一些新型类似物是出人意料的强效且选择性的雌激素受体β配体。
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