Bridged androstenediol analogs as ER-beta selective SERMs.
作者信息
Blizzard Timothy A, Gude Candido, Chan Wanda, Birzin Elizabeth T, Mojena Marina, Tudela Consuelo, Chen Fang, Knecht Kristin, Su Qin, Kraker Bryan, Holmes Mark A, Rohrer Susan P, Hammond Milton L
机构信息
Merck Research Laboratories, PO Box 2000, Rahway, NJ 07065, USA.
出版信息
Bioorg Med Chem Lett. 2007 May 15;17(10):2944-8. doi: 10.1016/j.bmcl.2006.12.053. Epub 2006 Dec 21.
PMID:17448656
Abstract
A series of bridged androstenediol derivatives was prepared. The bridged compounds exhibited reduced ER-beta selectivity relative to uncyclized analogs.
摘要
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