Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Avenue, New York, New York 10065, USA.
J Am Chem Soc. 2010 Mar 31;132(12):4427-30. doi: 10.1021/ja910825g.
A mild and efficient two-carbon homologation of aldehydes exploiting multiple modes of KOt-Bu was developed. This process involves a sequential Peterson allenylation/allene-alkyne isomerization/protodesilylation in a single-flask operation. The differential roles played by the various elements of the process were demonstrated through dissection experiments.
发展了一种温和高效的利用 KOt-Bu 多种模式的醛的两碳同系化方法。该过程在单瓶操作中涉及 Peterson 烯丙基化/丙二烯炔烃异构化/脱硅烷化的顺序反应。通过分解实验证明了该过程中各个元素的不同作用。
