Turker Gulcan, Ergen Kivanç, Karakoç Yunus, Arisoy Ayşe Engin, Barutcu U Bora
Department of Pediatrics, Neonatology Division, Kocaeli University Faculty of Medicine, Kocaeli, Turkey.
Biol Neonate. 2006;89(4):244-50. doi: 10.1159/000089953. Epub 2005 Nov 24.
To investigate fetal exposure to toxic metals [lead (Pb), cadmium (Cd)] and fetal levels of trace elements [zinc (Zn), copper (Cu), and iron (Fe)] in newborns from an industrial city. Relationships between meconium mineral contents and parental occupation and location of residence were also tested.
The meconium mineral contents of 117 healthy newborn infants were measured by flame atomic absorption spectrophotometer.
The median concentrations (interquartile range) of toxic metals and trace elements in the meconium were as follows: Pb: 46.5 (1,399) microg/g dry weight (wt), Cd: 2.3 (55.6) microg/g dry wt; Zn: 234 (3,049) microg/g dry wt; Cu: 11.8 (818.7) microg/g dry wt, and Fe 105 (2,980) microg/g dry wt. All the meconium samples contained both toxic metals and trace elements. The proportions of trace elements in the meconium samples with concentration higher than 100 microg/g dry wt of the substances tested were Zn 90%, Cu 64%, and Fe 53%. There were significantly positive correlations between the concentrations of toxic metals and trace elements. Also there were positive correlations between the levels of Zn, Fe, and parental occupations, and between the level of Fe and location of residence of the parents (proximity to the petroleum refinery or the dye industries).
All the meconium samples were positive for toxic metals, and thus may reflect environmental pollution in the city. The occupation environments and the location of the family residence are linked with levels of trace elements in meconium.
调查工业城市中新生儿胎儿期接触有毒金属（铅、镉）的情况以及胎儿体内微量元素（锌、铜、铁）的水平。同时还检测了胎粪矿物质含量与父母职业及居住地点之间的关系。
采用火焰原子吸收分光光度计测量117例健康新生儿的胎粪矿物质含量。
胎粪中有毒金属和微量元素的中位数浓度（四分位间距）如下：铅：46.5（1,399）μg/g干重，镉：2.3（55.6）μg/g干重；锌：234（3,049）μg/g干重；铜：11.8（818.7）μg/g干重，铁：105（2,980）μg/g干重。所有胎粪样本均含有有毒金属和微量元素。在所检测物质中，胎粪样本中浓度高于100μg/g干重的微量元素比例分别为：锌90%、铜64%、铁53%。有毒金属与微量元素的浓度之间存在显著正相关。锌、铁水平与父母职业之间以及铁水平与父母居住地点（靠近炼油厂或染料厂）之间也存在正相关。
所有胎粪样本的有毒金属检测均呈阳性，因此可能反映了该城市的环境污染情况。职业环境和家庭居住地点与胎粪中微量元素水平有关。
