Quang Dang Ngoc, Hashimoto Toshihiro, Stadler Marc, Radulović Niko, Asakawa Yoshinori
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Planta Med. 2005 Nov;71(11):1058-62. doi: 10.1055/s-2005-873129.
Four new azaphilones named multiformins A - D together with a known compound 4 : 5:4':5'-tetrahydroxy-1 : 1'-binaphthyl were isolated from the methanolic stromatal extract of the xylariaceous ascomycete Hypoxylon multiforme. Their absolute structures were characterised by 2D-NMR, UV, IR, mass and CD spectroscopy. Multiformins A - D showed strong and apparently non-selective antimicrobial activity.
从炭角菌科子囊菌多形炭团菌的甲醇基质提取物中分离出四种新的氮杂蒽酮类化合物,命名为多形菌素A - D,以及一种已知化合物4 : 5:4':5'-四羟基-1 : 1'-联萘。通过二维核磁共振、紫外、红外、质谱和圆二色光谱对它们的绝对结构进行了表征。多形菌素A - D表现出强烈且明显无选择性的抗菌活性。