Hu Ming, Watson Chris J, Kennedy Robert T, Becker Jill B
Psychology Department, University of Michigan, Ann Arbor, Michigan 48109, USA.
Synapse. 2006 Feb;59(2):122-4. doi: 10.1002/syn.20221.
Estradiol acts rapidly and directly to inhibit L-type Ca2+ current in medium spiny neurons from striatum. Since medium spiny neurons contain gamma-aminobutyric acid (GABA), we hypothesized that estradiol inhibition of Ca2+ channel current in the cell body would result in decreased GABA release. In this study, we examined the effect of estradiol on the concentration of GABA, taurine, and glutamate in dialysate from striatum. In support of our hypothesis, the K+-evoked increase in GABA, but not taurine or glutamate, was significantly attenuated 30 min after treatment with estradiol.
雌二醇可迅速直接抑制纹状体中型多棘神经元中的L型Ca2+电流。由于中型多棘神经元含有γ-氨基丁酸（GABA），我们推测雌二醇对细胞体中Ca2+通道电流的抑制作用会导致GABA释放减少。在本研究中，我们检测了雌二醇对纹状体透析液中GABA、牛磺酸和谷氨酸浓度的影响。为支持我们的假设，用雌二醇处理30分钟后，K+诱发的GABA增加（而非牛磺酸或谷氨酸增加）显著减弱。
