Arif Saatea, Hanif Ruhila, Khan A Sattar, Mufti Taufeeq Ahmed
Department of Biochemistry, Khyber Medical College, Peshawar.
J Ayub Med Coll Abbottabad. 2005 Jul-Sep;17(3):54-7.
Cirrhosis liver claims many lives in our country. However early diagnosis carries good prognosis and prevents complications. Estimation of serum sialic acid level may be helpful in the diagnosis of liver cirrhosis and following the dynamics of the disease especially during treatment and follow up to see the prognosis.
Sialic acid level of 82 confirmed liver cirrhosis patients of age between 18-60 years and admitted in Khyber Teaching Hospital Peshawar was determined and compared with 40 normal controls. The patients were studied in three groups according to the stage of the disease, i.e. the patients in early stages, in advancing stage, and those in terminal stage of liver cirrhosis. Sialic acid level was determined on HPLC (Hitachi) with D-2500 chromatographer.
Significantly high levels of sialic acid were recorded in patients as compared to controls. It was normal in early stage of liver cirrhosis (667 +/- 8.06 nmol/ml), markedly increased in advancing cirrhosis (952 +/- 3.29 nmol/ml) (P<0.05) and very high levels were observed in terminal stage (1058 +/- 7.50 nmol/ml).
Serum Sialic acid level was high in advancing and terminal stages of disease as compared to early stage and controls that showed normal levels.
肝硬化在我国导致许多人死亡。然而，早期诊断预后良好并可预防并发症。血清唾液酸水平的评估可能有助于肝硬化的诊断以及跟踪疾病动态，特别是在治疗和随访期间以了解预后情况。
测定了白沙瓦开伯尔教学医院收治的82例年龄在18至60岁之间的确诊肝硬化患者的唾液酸水平，并与40名正常对照进行比较。根据疾病阶段将患者分为三组，即肝硬化早期、进展期和终末期患者。使用配备D - 2500色谱仪的日立高效液相色谱仪（HPLC）测定唾液酸水平。
与对照组相比，患者的唾液酸水平显著升高。肝硬化早期唾液酸水平正常（667±8.06纳摩尔/毫升），进展期肝硬化显著升高（952±3.29纳摩尔/毫升）（P<0.05），终末期唾液酸水平非常高（1058±7.50纳摩尔/毫升）。
与早期及唾液酸水平正常的对照组相比，疾病进展期和终末期患者的血清唾液酸水平较高。
