Gruszewska Ewa, Cylwik Bogdan, Panasiuk Anatol, Szmitkowski Maciej, Flisiak Robert, Chrostek Lech
Department of Biochemical Diagnostics, Medical University of Bialystok, Waszyngtona 15A Street, 15-269 Bialystok, Poland.
Department of Pediatric Laboratory Diagnostics, Medical University of Bialystok, Waszyngtona 17 Street, 15-269 Bialystok, Poland.
Biomed Res Int. 2014;2014:876096. doi: 10.1155/2014/876096. Epub 2014 May 18.
The objective of this study was to compare the levels of total (TSA) and free (FSA) sialic acid in acute and chronic liver diseases. MaTERIALS AND METHODS: The serum TSA and FSA levels were determined in 278 patients suffering from acute and chronic liver diseases of different etiologies. TSA was estimated by enzymatic method and FSA by the thiobarbituric method modified by Skoza and Mohos.
There were no significant differences in the serum TSA concentration between liver diseases of different etiologies, although in most of the liver diseases the mean TSA level was significantly lower than that in the control group. In contrast to TSA, the concentration of FSA appears to differ between liver diseases. In toxic hepatitis it was higher than that in nonalcoholic cirrhosis. However, neither of them differs between alcoholic and nonalcoholic cirrhosis or between liver tumors and tumors with cirrhosis.
We conclude that the changes in concentrations of TSA and FSA during the same liver diseases indicate significant disturbances in sialylation of serum glycoproteins.
本研究的目的是比较急性和慢性肝病中总唾液酸（TSA）和游离唾液酸（FSA）的水平。
测定了278例不同病因的急性和慢性肝病患者的血清TSA和FSA水平。TSA采用酶法测定，FSA采用Skoza和Mohos改良的硫代巴比妥酸法测定。
不同病因的肝病之间血清TSA浓度无显著差异，尽管在大多数肝病中，TSA的平均水平显著低于对照组。与TSA不同，FSA的浓度在不同肝病之间似乎有所不同。在中毒性肝炎中，FSA浓度高于非酒精性肝硬化。然而，在酒精性和非酒精性肝硬化之间，或在肝肿瘤与伴有肝硬化的肿瘤之间，两者均无差异。
我们得出结论，在同一肝病过程中TSA和FSA浓度的变化表明血清糖蛋白的唾液酸化存在显著紊乱。
