迈向新型聚酮类天然产物刺孢酸A的全合成。
Toward a total synthesis of the novel polyketide natural product spiculoic acid A.
作者信息
Mehta Goverdhan, Kundu Uday Kumar
机构信息
Department of Organic Chemistry, Indian Institute of Science, Bangalore 560012, India.
出版信息
Org Lett. 2005 Dec 8;7(25):5569-72. doi: 10.1021/ol0521329.
PMID:16320993
Abstract
[chemical reaction: see text]. An enantioselective approach toward the recently isolated marine natural product, spiculoic acid A, conceptualized along the proposed biogenetic hypothesis, involving an intramolecular Diels-Alder reaction as the pivotal step, is delineated. Access to a structurally embellished bicyclic core of the natural product has been accomplished.
摘要
[化学反应：见正文]。根据提出的生源假说，设计了一种对映选择性合成方法，用于合成最近分离出的海洋天然产物spiculoic acid A，该方法以分子内狄尔斯-阿尔德反应为关键步骤。现已实现了对该天然产物结构修饰的双环核心的合成。
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