异、去甲和双去甲海绵酸A，来自海洋海绵动物齐格蒙法扁海绵的聚酮化合物。
Iso-, nor-, and dinor-spiculoic acids A, polyketides from the marine sponge Plakortis zyggompha.
作者信息
Berrué Fabrice, Thomas Olivier P, Fernández Rogelio, Amade Philippe
机构信息
Laboratoire de Chimie Bioorganique, UMR 6001 CNRS, Faculté des Science, UNSA, Parc Valrose, 06108 Nice Cedex 02, France.
出版信息
J Nat Prod. 2005 Apr;68(4):547-9. doi: 10.1021/np049602c.
The new iso-, nor-, and dinor-spiculoic acids A (1, 2, and 3, respectively) with a rare spiculane skeleton were isolated from the marine sponge Plakortis zyggompha, collected in the waters south of Martinique. The structural determination of the compounds was based on 1D and 2D NMR studies and mass spectral determinations. Compounds 1 and 2 showed weak cytotoxicity against the two tumor cell lines A549 and HT29.
从采集于马提尼克岛以南水域的海洋海绵动物齐格姆帕氏扁海绵（Plakortis zyggompha）中分离出了具有罕见的针骨烷骨架的新型异、去甲和双去甲海绵酸A（分别为1、2和3）。化合物的结构测定基于一维和二维核磁共振研究以及质谱测定。化合物1和2对两种肿瘤细胞系A549和HT29显示出微弱的细胞毒性。
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