Cieplak Marek, Sułkowska Joanna I
Institute of Physics, Polish Academy of Sciences, Aleja Lotników 32/46, 02-668 Warsaw, Poland.
J Chem Phys. 2005 Nov 15;123(19):194908. doi: 10.1063/1.2121668.
Thermal unfolding of proteins is compared to folding and mechanical stretching in a simple topology-based dynamical model. We define the unfolding time and demonstrate its low-temperature divergence. Below a characteristic temperature, contacts break at separate time scales and unfolding proceeds approximately in a way reverse to folding. Features in these scenarios agree with experiments and atomic simulations on titin.
在一个基于简单拓扑结构的动力学模型中，将蛋白质的热解折叠与折叠和机械拉伸进行了比较。我们定义了解折叠时间，并证明了其在低温下的发散。低于特征温度时，接触在不同的时间尺度上断裂，解折叠过程大致以与折叠相反的方式进行。这些情况中的特征与关于肌联蛋白的实验和原子模拟结果一致。
