Norlander T, Forsgren K, Kumlien J, Stierna P, Carlsöö B
Department of Otorhinolaryngology, Huddinge University Hospital, Karolinska Institute, Sweden.
Acta Otolaryngol Suppl. 1992;492:33-7. doi: 10.3109/00016489209136805.
Unilateral maxillary sinusitis was induced in 30 New Zealand White rabbits with Streptococcus pneumoniae or Bacteroides fragilis. In another group of 15 rabbits without infection, the sinus mucosa was surgically removed in defined areas. In both series, the sinuses were serially sectioned for histological analysis of the cellular regenerative capacity. In maxillary sinusitis induced by Bacteroides fragilis, an inflammatory and also reparative process involving all mucosal layers including the underlying periosteum was seen. The more superficial trauma as found in pneumococcal sinusitis eventually led to restitution ad integrum. Following surgical removal, the denuded sinus-lining was reepithelized by a flattened ciliated epithelium on a lamina propria displaying fibrosis and lacking serous glands. The restoration of the rabbit maxillary sinus mucosa after surgical trauma thus leads to structural abnormalities of the epithelium as well as the lamina propria, and these changes are likely to interfere with the normal function of the sinus mucosa.
用肺炎链球菌或脆弱拟杆菌诱导30只新西兰白兔发生单侧上颌窦炎。在另一组15只未感染的兔子中，在特定区域手术切除鼻窦黏膜。在这两个系列中，鼻窦均进行连续切片，以对细胞再生能力进行组织学分析。在脆弱拟杆菌引起的上颌窦炎中，可见包括深层骨膜在内的所有黏膜层均出现炎症及修复过程。肺炎球菌性鼻窦炎中发现的较浅表创伤最终导致完全恢复。手术切除后，裸露的鼻窦内衬由扁平的纤毛上皮重新上皮化，固有层显示纤维化且缺乏浆液腺。因此，手术创伤后兔上颌窦黏膜的恢复会导致上皮及固有层结构异常，这些变化可能会干扰鼻窦黏膜的正常功能。
