Pentheroudakis George, Pavlidis Nicholas
Department of Medical Oncology, Ioannina University Hospital, University of Ioannina, 45 110 Ioannina, Greece.
Eur J Cancer. 2006 Jan;42(2):126-40. doi: 10.1016/j.ejca.2005.10.014. Epub 2005 Dec 2.
Cancer diagnosed during pregnancy constitutes a difficult clinical condition with a devastating impact on the patient's somatic and psychosocial health and possibly on foetal integrity. This circumstance also raises several moral, religious, social and familial dilemmas. In this review we critically present available evidence regarding the incidence, epidemiology and genetics of cancer in pregnant women, its presentation, diagnosis and staging as well as therapeutic management. Issues such as maternal/foetal prognosis, need for termination of pregnancy, risk of foetal health injury and necessity of psychosocial support are reviewed. Recent accumulating evidence suggests that, with appropriate management, poena magna should not be used to define neither cancer nor pregnancy.
孕期诊断出癌症是一种棘手的临床情况，会对患者的躯体和心理社会健康产生毁灭性影响，甚至可能影响胎儿的完整性。这种情况还引发了一些道德、宗教、社会和家庭方面的困境。在本综述中，我们批判性地呈现了关于孕妇癌症的发病率、流行病学、遗传学、临床表现、诊断、分期以及治疗管理的现有证据。对诸如母婴预后、终止妊娠的必要性、胎儿健康受损风险以及心理社会支持的必要性等问题进行了综述。最近越来越多的证据表明，通过适当的管理，不应将“大祸临头”用来定义癌症或妊娠。
