抗伯氏疏螺旋体IgG抗体血清阳性与颈动脉粥样硬化独立相关。

Seropositivity for anti-Borrelia IgG antibody is independently associated with carotid atherosclerosis.

作者信息

Völzke Henry, Wolff Birger, Lüdemann Jan, Guertler Lutz, Kramer Axel, John Ulrich, Felix Stephan B

机构信息

Institute of Epidemiology and Social Medicine, Ernst Moritz Arndt University Greifswald, Walther-Rathenau-Str. 48, D-17487 Greifswald, Germany.

出版信息

Atherosclerosis. 2006 Jan;184(1):108-12. doi: 10.1016/j.atherosclerosis.2004.10.048. Epub 2005 Apr 26.

DOI:10.1016/j.atherosclerosis.2004.10.048

PMID:16326170

Abstract

BACKGROUND

Various infectious agents are associated with atherosclerosis. This analysis was performed to investigate relation between seropositivity for anti-Borrelia IgG and carotid atherosclerosis.

METHODS

The cross-sectional Study of Health in Pomerania was conducted in a general community living in a region with endemic Lyme disease. A random sample of 2483 individuals aged 45-79 years was available for the present analysis. Carotid atherosclerosis was sonographically assessed as intima-media thickness of the common carotid artery and as prevalent atherosclerotic plaques in the extracranial carotid arteries. IgG antibodies to Borrelia were determined by ELISA.

RESULTS

IgG antibodies to Borrelia were found positive (> 10 IU/mL) in 108 subjects (4.3%). Persons with and without positive anti-Borrelia IgG antibodies differed with respect to carotid intima-media thickness values (0.863 +/- 0.017 mm versus 0.792 +/- 0.004 mm; p < 0.001) and prevalent carotid plaques (odds ratio 2.65, 95% confidence interval 1.53-4.61; p = 0.001), respectively. Seropositivity for anti-Borrelia IgG was also associated with both atherosclerotic endpoints when age, sex and further atherogenic risk factors and confounders were included in multivariable statistical models.

CONCLUSIONS

In a region with endemic Lyme disease, seropositivity for anti-Borrelia IgG antibodies is independently associated with atherosclerosis. Our findings add support to the hypothesis that exposure to infectious pathogens increases the atherosclerosis risk.

摘要

背景

多种感染因子与动脉粥样硬化相关。本分析旨在研究抗伯氏疏螺旋体IgG血清阳性与颈动脉粥样硬化之间的关系。

方法

在一个莱姆病流行地区的普通社区开展了波美拉尼亚健康横断面研究。本分析采用了2483名年龄在45 - 79岁之间的随机样本个体。通过超声检查评估颈动脉粥样硬化，测量颈总动脉的内膜中层厚度以及颅外颈动脉中动脉粥样硬化斑块的患病率。采用酶联免疫吸附测定法检测抗伯氏疏螺旋体的IgG抗体。

结果

108名受试者（4.3%）的抗伯氏疏螺旋体IgG抗体呈阳性（>10 IU/mL）。抗伯氏疏螺旋体IgG抗体阳性和阴性的人群在颈动脉内膜中层厚度值方面存在差异（分别为0.863±0.017 mm和0.792±0.004 mm；p<0.001），在颈动脉斑块患病率方面也存在差异（优势比为2.65，95%置信区间为1.53 - 4.61；p = 0.001）。当在多变量统计模型中纳入年龄、性别以及其他致动脉粥样硬化危险因素和混杂因素时，抗伯氏疏螺旋体IgG血清阳性也与两种动脉粥样硬化终点相关。