Kiank C, Holtfreter B, Starke A, Mundt A, Wilke C, Schütt C
Department of Immunology, University of Greifswald, Germany.
Brain Behav Immun. 2006 Jul;20(4):359-68. doi: 10.1016/j.bbi.2005.10.151. Epub 2005 Dec 2.
Chronic psychological stress has been suggested to play a role in disorders in which the immune system unexpectedly fails to respond in a protective manner. Chronic combined acoustic and restraint stress compromises the anti-bacterial defense mechanisms of female BALB/c mice. The immunodeficiency is characterized by an apoptotic loss of lymphocytes, reduced ex vivo-inducibility of TNF but increased inducibility of IL10, reduced T-cell proliferation, and impaired phagocyte functions. Stressed mice develop depression-like behavior that was monitored by a stress severity score (SSS). Besides a strain (BALB/c>CBA) and gender (male>female) dependent susceptibility to chronic stress, inbred mice have an individual coping ability. Importantly, the individual SSS strongly correlates with Escherichia coli dissemination after infection as well as with IL10-inducibility and circulating corticosterone levels of each animal.
慢性心理应激被认为在免疫系统意外无法以保护方式做出反应的疾病中起作用。慢性联合声学和束缚应激会损害雌性BALB/c小鼠的抗菌防御机制。这种免疫缺陷的特征是淋巴细胞凋亡性损失、肿瘤坏死因子（TNF）体外诱导性降低但白细胞介素10（IL10）诱导性增加、T细胞增殖减少以及吞噬细胞功能受损。应激小鼠会出现类似抑郁的行为，通过应激严重程度评分（SSS）进行监测。除了品系（BALB/c>CBA）和性别（雄性>雌性）对慢性应激的易感性外，近交系小鼠还有个体应对能力。重要的是，个体SSS与感染后大肠杆菌的传播以及每只动物的IL10诱导性和循环皮质酮水平密切相关。
