[子痫前期和妊娠期高血压患者血清辅助性T细胞1型和2型细胞因子失衡]
[Imbalance of serum T helper 1- and 2-type cytokines in preeclampsia and gestational hypertension].
作者信息
Dong Min-yue, Shi Xiao-liang, He Jing, Wang Zheng-ping, Xie Xing, Wang Han-zhi
机构信息
The Affiliated Obstetrics and Gynecology Hospital, College of Medicine, Zhejiang University, Hangzhou 310006, China.
出版信息
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2005 Nov;34(6):488-91. doi: 10.3785/j.issn.1008-9292.2005.06.002.
OBJECTIVE
To investigate the changes in serum levels of Th1- (IL-2 and TNF-alpha) and Th2-type cytokines (IL-10) and the ratios of Th1/Th2 (IL-2/IL-10 and TNF-alpha/IL-10) in preeclampsia and in gestational hypertension.
METHODS
Levels of IL-2, IL-10 and TNF-alpha were determined with radioimmunoassay in serum samples from 22 women with preeclampsia, 15 women with gestational hypertension and 32 normal term pregnant women. The Th1/Th2 ratios were calculated accordingly.
RESULT
There were no significant differences in serum levels of IL-2, IL-10 and TNF-alpha (P>0.05 for all) among normal pregnancy, gestational hypertension and preeclampsia. The ratio of serum IL-2/IL-10 was significantly higher in preeclampsia than that in controls (P < 0.05), and the ratio of TNF-alpha/IL-10 significantly higher in patients with preeclampsia than that in either controls or gestational hypertension (P<0.025 for both).
CONCLUSION
Alterations of serum cytokine balance with predominance of Th1 immunity were observed in preeclampsia. These associations may offer insight into the pathogenesis of preeclampsia.
目的
研究子痫前期和妊娠期高血压患者血清中Th1型细胞因子（白细胞介素-2和肿瘤坏死因子-α）、Th2型细胞因子（白细胞介素-10）水平变化以及Th1/Th2比值（白细胞介素-2/白细胞介素-10和肿瘤坏死因子-α/白细胞介素-10）。
方法
采用放射免疫分析法测定22例子痫前期患者、15例妊娠期高血压患者和32例足月正常孕妇血清样本中白细胞介素-2、白细胞介素-10和肿瘤坏死因子-α水平，并计算Th1/Th2比值。
结果
正常妊娠、妊娠期高血压和子痫前期患者血清中白细胞介素-2、白细胞介素-10和肿瘤坏死因子-α水平差异均无统计学意义（P均>0.05）。子痫前期患者血清白细胞介素-2/白细胞介素-10比值显著高于对照组（P<0.05），子痫前期患者肿瘤坏死因子-α/白细胞介素-10比值显著高于对照组和妊娠期高血压患者（P均<0.025）。
结论
子痫前期患者血清细胞因子平衡发生改变，以Th1免疫为主导。这些关联可能为子痫前期的发病机制提供线索。
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