Libby Richard T, Anderson Michael G, Pang Iok-Hou, Robinson Zachary H, Savinova Olga V, Cosma I Mihai, Snow Amy, Wilson Lawriston A, Smith Richard S, Clark Abbot F, John Simon W M
The Jackson Laboratory, Bar Harbor, ME 04609, USA.
Vis Neurosci. 2005 Sep-Oct;22(5):637-48. doi: 10.1017/S0952523805225130.
The glaucomas are neurodegenerative diseases involving death of retinal ganglion cells and optic nerve head excavation. A major risk factor for this neurodegeneration is a harmfully elevated intraocular pressure (IOP). Human glaucomas are typically complex, progressive diseases that are prevalent in the elderly. Family history and genetic factors are clearly important in human glaucoma. Mouse studies have proven helpful for investigating the genetic and mechanistic basis of complex diseases. We previously reported inherited, age-related progressive glaucoma in DBA/2J mice. Here, we report our updated findings from studying the disease in a large number of DBA/2J mice. The period when mice have elevated IOP extends from 6 months to 16 months, with 8-9 months representing an important transition to high IOP for many mice. Optic nerve degeneration follows IOP elevation, with the majority of optic nerves being severely damaged by 12 months of age. This information should help with the design of experiments, and we present the data in a manner that will be useful for future studies of retinal ganglion cell degeneration and optic neuropathy.
青光眼是涉及视网膜神经节细胞死亡和视神经乳头凹陷的神经退行性疾病。这种神经退行性变的一个主要危险因素是眼内压（IOP）有害升高。人类青光眼通常是复杂的、进行性疾病，在老年人中很常见。家族史和遗传因素在人类青光眼中显然很重要。小鼠研究已证明有助于研究复杂疾病的遗传和机制基础。我们之前报道了DBA/2J小鼠遗传性、年龄相关性进行性青光眼。在此，我们报告在大量DBA/2J小鼠中研究该疾病的最新发现。小鼠IOP升高的时期从6个月持续到16个月，8 - 9个月对许多小鼠来说是向高IOP的重要转变期。IOP升高后会出现视神经变性，到12月龄时，大多数视神经会受到严重损伤。这些信息应有助于实验设计，并且我们以一种对未来视网膜神经节细胞变性和视神经病变研究有用的方式呈现数据。
