John S W, Smith R S, Savinova O V, Hawes N L, Chang B, Turnbull D, Davisson M, Roderick T H, Heckenlively J R
Jackson Laboratory, Bar Harbor, Maine 04609, USA.
Invest Ophthalmol Vis Sci. 1998 May;39(6):951-62.
To characterize ocular abnormalities associated with iris atrophy in DBA/2J mice and to determine whether mice of this strain develop elevated intraocular pressure (IOP) and glaucoma.
Different approaches, including slit-lamp biomicroscopy, ophthalmoscopic examination, ultrasound backscatter microscopy, and histology were used to examine the eyes of DBA/2J mice ranging from 2 to 30 months old. IOP was measured in DBA/2J mice of different ages.
DBA/2J mice were found to develop pigment dispersion, iris transillumination, iris atrophy, anterior synechias, and elevated IOP. IOP was elevated in most mice by the age of 9 months. These changes were followed by the death of retinal ganglion cells, optic nerve atrophy, and optic nerve cupping. The prevalence and severity of these lesions increased with age. Optic nerve atrophy and optic nerve cupping was present in the majority of mice by the age of 22 months.
DBA/2J mice develop a progressive form of secondary angle-closure glaucoma that appears to be initiated by iris atrophy and the associated formation of synechias. This mouse strain represents a useful model to evaluate mechanisms of pressure-related ganglion cell death and optic nerve atrophy, and to evaluate strategies for neuroprotection.
描述DBA/2J小鼠中与虹膜萎缩相关的眼部异常，并确定该品系小鼠是否会出现眼压升高和青光眼。
采用不同方法，包括裂隙灯生物显微镜检查、检眼镜检查、超声背向散射显微镜检查和组织学检查，对2至30月龄的DBA/2J小鼠眼睛进行检查。测量不同年龄DBA/2J小鼠的眼压。
发现DBA/2J小鼠出现色素播散、虹膜透照、虹膜萎缩、虹膜前粘连和眼压升高。大多数小鼠在9月龄时眼压升高。这些变化随后伴有视网膜神经节细胞死亡、视神经萎缩和视神经杯状凹陷。这些病变的发生率和严重程度随年龄增加。到22月龄时，大多数小鼠出现视神经萎缩和视神经杯状凹陷。
DBA/2J小鼠发生一种进行性继发性闭角型青光眼，似乎由虹膜萎缩及相关的虹膜粘连形成引发。该小鼠品系是评估压力相关神经节细胞死亡和视神经萎缩机制以及评估神经保护策略的有用模型。
