Nasereddin Abedelmajeed, Baneth Gad, Schönian Gabriele, Kanaan Moein, Jaffe Charles L
Department of Parasitology, Hebrew University-Hadassah Medical School, P.O. Box 12272, Jerusalem 91220, Israel.
J Clin Microbiol. 2005 Dec;43(12):6054-9. doi: 10.1128/JCM.43.12.6054-6059.2005.
Human and canine visceral leishmaniasis caused by Leishmania infantum emerged in central Israel after an absence of over 30 years. The origin of this outbreak was investigated by examining genetic polymorphisms in 37 strains isolated from dogs and patients with visceral leishmaniasis in the continuously active northern Israeli and West Bank foci and in a new Israeli focus using DNA fingerprinting with the human multilocus minisatellite probe 33.15. Analysis of the patterns obtained by DNA fingerprinting separated the strains geographically into northern (clade B) and central (clades A and C) genotypic groups. These results suggest that the emergence of visceral leishmaniasis in central Israel is due not to parasite spread from northern Israel to the new focus but rather to increased parasite transmission in central Israel and the West Bank coupled with changes in the ecoepidemiology of this region.
在以色列中部，婴儿利什曼原虫引起的人类和犬类内脏利什曼病在消失30多年后再度出现。通过使用人类多位点小卫星探针33.15进行DNA指纹分析，研究了此次疫情的起源，分析对象为从以色列北部持续活跃的病灶、约旦河西岸病灶以及以色列一个新病灶中分离出的37株来自犬类和内脏利什曼病患者的菌株。对DNA指纹分析得到的图谱进行分析后，按地理区域将菌株分为北部（进化枝B）和中部（进化枝A和C）基因型组。这些结果表明，以色列中部内脏利什曼病的出现并非是寄生虫从以色列北部传播到新病灶所致，而是由于以色列中部和约旦河西岸寄生虫传播增加，以及该地区生态流行病学发生了变化。
