Griffith J, Dieckmann M, Berg P
J Virol. 1975 Jan;15(1):167-72. doi: 10.1128/JVI.15.1.167-172.1975.
A salt-stable complex of protein and viral DNA obtained from Simian virus 40 (SV40)-infected monkey cells or mature SV40 virions has a novel structure. When viewed by high resolution electron microscopy, the circular SV40 DNA molecule has bound to it one to three globular protein "knobs". Using ecoRI and hpaII restriction endonucleases, each of which can cleave SV40 DNA once at a known location (10, 11, 12, 14), the bound protein can be localized at 0.7 plus or minis 0.05 on the SV40 DNA physical map (SV40 fractional length, clockwise from the ecoRI endonuclease-cleavage site).
从感染猿猴病毒40（SV40）的猴细胞或成熟的SV40病毒粒子中获得的蛋白质与病毒DNA的盐稳定复合物具有一种新结构。通过高分辨率电子显微镜观察时，环状SV40 DNA分子上结合有一到三个球状蛋白质“瘤”。使用EcoRI和HpaII限制性内切酶，它们各自可在已知位置（10、11、12、14）切割SV40 DNA一次，结合的蛋白质可定位在SV40 DNA物理图谱上0.7±0.05处（SV40分数长度，从EcoRI内切酶切割位点顺时针方向）。
