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1
The basic RNA polymerase II transcriptional machinery.基本的RNA聚合酶II转录机制。
Gene Expr. 1992;2(2):81-91.
2
A mouse in vitro transcription system reconstituted from highly purified RNA polymerase II, TFIIH and recombinant TBP, TFIIB, TFIIE and TFIIF.一种由高度纯化的RNA聚合酶II、TFIIH以及重组TBP、TFIIB、TFIIE和TFIIF重构的小鼠体外转录系统。
Eur J Biochem. 2001 Aug;268(16):4527-36. doi: 10.1046/j.1432-1327.2001.02378.x.
3
Factors involved in specific transcription by mammalian RNA polymerase II: identification of general transcription factor TFIIG.哺乳动物RNA聚合酶II特异性转录所涉及的因子：通用转录因子TFIIG的鉴定。
Proc Natl Acad Sci U S A. 1990 Dec;87(23):9158-62. doi: 10.1073/pnas.87.23.9158.
4
Factors involved in specific transcription by mammalian RNA polymerase II. Identification and characterization of factor IIH.哺乳动物RNA聚合酶II特异性转录所涉及的因子。因子IIH的鉴定与特性分析。
J Biol Chem. 1992 Feb 5;267(4):2786-93.
5
Five intermediate complexes in transcription initiation by RNA polymerase II.RNA聚合酶II转录起始过程中的五个中间复合物。
Cell. 1989 Feb 24;56(4):549-61. doi: 10.1016/0092-8674(89)90578-3.
6
Molecular genetics of the RNA polymerase II general transcriptional machinery.RNA聚合酶II通用转录机制的分子遗传学
Microbiol Mol Biol Rev. 1998 Jun;62(2):465-503. doi: 10.1128/MMBR.62.2.465-503.1998.
7
A transcription factor IIA-binding site differentially regulates RNA polymerase II-mediated transcription in a promoter context-dependent manner.转录因子IIA结合位点以启动子背景依赖的方式差异性地调节RNA聚合酶II介导的转录。
J Biol Chem. 2017 Jul 14;292(28):11873-11885. doi: 10.1074/jbc.M116.770412. Epub 2017 May 24.
8
Transcription. Riding high on the TATA box.转录。依赖于TATA框。
Nature. 1992 Nov 5;360(6399):16-7. doi: 10.1038/360016a0.
9
The general transcription machinery and general cofactors.通用转录机制和通用辅因子。
Crit Rev Biochem Mol Biol. 2006 May-Jun;41(3):105-78. doi: 10.1080/10409230600648736.
10
Identification of a minimal set of proteins that is sufficient for accurate initiation of transcription by RNA polymerase II.鉴定一组最小的蛋白质，其足以使RNA聚合酶II准确起始转录。
Genes Dev. 1993 Jul;7(7A):1254-65. doi: 10.1101/gad.7.7a.1254.

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Nuclear Transfer Arrest Embryos Show Massive Dysregulation of Genes Involved in Transcription Pathways.核移植阻滞胚胎显示转录途径相关基因的广泛失调。
Int J Mol Sci. 2021 Jul 30;22(15):8187. doi: 10.3390/ijms22158187.
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Isolation and characterization of Aquaporin 1 (AQP1), sodium/potassium-transporting ATPase subunit alpha-1 (Na/K-ATPase α1), Heat Shock Protein 90 (HSP90), Heat Shock Cognate 71 (HSC71), Osmotic Stress Transcription Factor 1 (OSTF1) and Transcription Factor II B (TFIIB) genes from a euryhaline fish, Etroplus suratensis.从广盐性鱼类苏拉特叶鲷中分离和鉴定水通道蛋白1（AQP1）、钠/钾转运ATP酶α-1亚基（Na/K-ATPase α1）、热休克蛋白90（HSP90）、热休克同源蛋白71（HSC71）、渗透应激转录因子1（OSTF1）和转录因子II B（TFIIB）基因。
Mol Biol Rep. 2018 Dec;45(6):2783-2789. doi: 10.1007/s11033-018-4350-1. Epub 2018 Sep 7.
3
Sfh1p, a component of a novel chromatin-remodeling complex, is required for cell cycle progression.Sfh1p是一种新型染色质重塑复合物的组成部分，是细胞周期进程所必需的。
Mol Cell Biol. 1997 Jun;17(6):3323-34. doi: 10.1128/MCB.17.6.3323.
4
Unusual charge configurations in transcription factors of the basic RNA polymerase II initiation complex.基本RNA聚合酶II起始复合物转录因子中的异常电荷配置。
Proc Natl Acad Sci U S A. 1993 Jun 15;90(12):5593-7. doi: 10.1073/pnas.90.12.5593.
5
The human immunodeficiency virus type 1 long terminal repeat specifies two different transcription complexes, only one of which is regulated by Tat.1型人类免疫缺陷病毒长末端重复序列可形成两种不同的转录复合物，其中只有一种受反式激活因子调控。
J Virol. 1993 Apr;67(4):1752-60. doi: 10.1128/JVI.67.4.1752-1760.1993.
6
C-terminal domain (CTD) of RNA-polymerase II and N-terminal segment of the human TATA binding protein (TBP) can mediate remote and proximal transcriptional activation, respectively.RNA聚合酶II的C末端结构域（CTD）和人类TATA结合蛋白（TBP）的N末端片段可分别介导远程和近端转录激活。
Nucleic Acids Res. 1993 Dec 11;21(24):5609-15. doi: 10.1093/nar/21.24.5609.
7
Evidence for a protein domain superfamily shared by the cyclins, TFIIB and RB/p107.细胞周期蛋白、TFIIB和RB/p107所共有的蛋白质结构域超家族的证据。
Nucleic Acids Res. 1994 Mar 25;22(6):946-52. doi: 10.1093/nar/22.6.946.
8
A C-terminal domain in FosB, absent in FosB/SF and Fra-1, which is able to interact with the TATA binding protein, is required for altered cell growth.FosB中存在而FosB/SF和Fra-1中不存在的一个C末端结构域能够与TATA结合蛋白相互作用，它是细胞生长改变所必需的。
EMBO J. 1994 Aug 15;13(16):3832-42. doi: 10.1002/j.1460-2075.1994.tb06694.x.
9
Modulation of transcriptional activation of the proliferating cell nuclear antigen promoter by the adenovirus E1A 243-residue oncoprotein depends on proximal activators.腺病毒E1A 243个氨基酸残基的癌蛋白对增殖细胞核抗原启动子转录激活的调节取决于近端激活因子。
Mol Cell Biol. 1994 Jan;14(1):543-53. doi: 10.1128/mcb.14.1.543-553.1994.
10
Identification of a mouse protein whose homolog in Saccharomyces cerevisiae is a component of the CCR4 transcriptional regulatory complex.一种小鼠蛋白的鉴定，其在酿酒酵母中的同源物是CCR4转录调控复合物的一个组分。
Mol Cell Biol. 1995 Jul;15(7):3487-95. doi: 10.1128/MCB.15.7.3487.

本文引用的文献

1
Multiple factors required for accurate initiation of transcription by purified RNA polymerase II.纯化的RNA聚合酶II准确起始转录需要多种因素。
J Biol Chem. 1980 Dec 25;255(24):11992-6.
2
Mechanism of RNA polymerase II--specific initiation of transcription in vitro: ATP requirement and uncapped runoff transcripts.RNA聚合酶II在体外特异性起始转录的机制：ATP需求与无帽延伸转录本
Cell. 1982 Jul;29(3):877-86. doi: 10.1016/0092-8674(82)90449-4.
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Mechanism of action of DRB. III. Effect on specific in vitro initiation of transcription.DRB的作用机制。III. 对体外特异性转录起始的影响。
J Mol Biol. 1983 Jul 5;167(3):561-74. doi: 10.1016/s0022-2836(83)80098-9.
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Formation of stable preinitiation complexes between eukaryotic class B transcription factors and promoter sequences.真核生物B类转录因子与启动子序列之间稳定前起始复合物的形成。
Nature. 1983 Feb 24;301(5902):680-6. doi: 10.1038/301680a0.
5
Interactions between RNA polymerase II, factors, and template leading to accurate transcription.RNA聚合酶II、因子与模板之间的相互作用导致精确转录。
J Biol Chem. 1984 Feb 25;259(4):2509-16.
6
Inhibitory effect of 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole on a protein kinase.5,6-二氯-1-β-D-呋喃核糖基苯并咪唑对一种蛋白激酶的抑制作用。
J Biol Chem. 1984 Dec 10;259(23):14804-11.
7
Is actin a transcription initiation factor for RNA polymerase B?肌动蛋白是RNA聚合酶B的转录起始因子吗？
EMBO J. 1984 Oct;3(10):2363-71. doi: 10.1002/j.1460-2075.1984.tb02141.x.
8
Purification and analysis of a factor which suppresses nick-induced transcription by RNA polymerase II and its identity with poly(ADP-ribose) polymerase.一种抑制RNA聚合酶II切口诱导转录的因子的纯化与分析及其与聚（ADP-核糖）聚合酶的同一性
J Biol Chem. 1983 May 10;258(9):5955-9.
9
Interaction of a gene-specific transcription factor with the adenovirus major late promoter upstream of the TATA box region.一种基因特异性转录因子与腺病毒主要晚期启动子在TATA框区域上游的相互作用。
Cell. 1985 Nov;43(1):165-75. doi: 10.1016/0092-8674(85)90021-2.
10
Purification and characterization of a specific RNA polymerase II transcription factor.一种特异性RNA聚合酶II转录因子的纯化与特性分析
J Biol Chem. 1986 Feb 15;261(5):2003-13.

基本的RNA聚合酶II转录机制。

The basic RNA polymerase II transcriptional machinery.

作者信息

Weinmann R

机构信息

Wistar Institute of Anatomy and Biology, Philadelphia, PA 19104.

出版信息

Gene Expr. 1992;2(2):81-91.

PMID:1633439
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6057384/
Abstract

All genes encoding proteins in eukaryotes are transcribed by RNA polymerase II. The first step in analyzing transcriptional regulation requires understanding the general mechanisms of RNA polymerase II-specific gene transcription. The basal promoter, a template containing a TATA box devoid of upstream regulatory sequences, has been used to identify and characterize the factors which, together with RNA polymerase II, govern transcription in mammalian systems: TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIG, TFIIH, and TFIIJ. Interactions between regulatory transcription factors and basal elements of the transcriptional machinery affect the transcriptional rate in a positive or negative fashion. As these multiple proteins are purified, and their coding sequences are isolated, we come closer to reproducing these processes in vitro with pure components, and thus to elucidating the complex interactions among them.

摘要

真核生物中所有编码蛋白质的基因均由RNA聚合酶II转录。分析转录调控的第一步需要了解RNA聚合酶II特异性基因转录的一般机制。基础启动子是一个不含上游调控序列的含有TATA框的模板，已被用于鉴定和表征与RNA聚合酶II一起在哺乳动物系统中调控转录的因子：TFIIA、TFIIB、TFIID、TFIIE、TFIIF、TFIIG、TFIIH和TFIIJ。调控转录因子与转录机制的基础元件之间的相互作用以正向或负向方式影响转录速率。随着这些多种蛋白质的纯化以及它们编码序列的分离，我们越来越接近于在体外使用纯组分重现这些过程，从而阐明它们之间复杂的相互作用。