Lai Kuang-Chi, Chen Wen-Chi, Tsai Fuu-Jen, Li Shuan-Yow, Chou Ming-Chih, Jeng Long-Bin
Department of Surgery, China Medical University Hospital, Taichung, Taiwan.
Hepatogastroenterology. 2005 Nov-Dec;52(66):1916-9.
BACKGROUND/AIMS: Glutathione S-transferases (GST) are involved in the detoxification of many potential carcinogens and appear to play an important role in the protection from carcinogens. The association between different GSTM1 genotypes and gastric cancer risk is still controversial. The aim of this study was to determine the association between the GSTM1-null genotype and gastric cancer risk.
A retrospective, hospital-based case-control study of 123 primary gastric cancer patients and 121 healthy controls was conducted to evaluate the presence or absence of the GSTM1 gene from peripheral blood samples by a PCR-based method.
The frequency of the GSTM1-null was 59.3% in the gastric cancer group and 45.5% in the control group. An increase in risk for gastric cancer was found among carriers of GSTM1-null genotype. The odds ratio (OR) was 1.752, with 95% confidence interval (CI) = 2.963 approximately 1.035.
GSTM1-null polymorphism was associated with genetic susceptibility of gastric cancer in Taiwan.
背景/目的：谷胱甘肽S-转移酶（GST）参与多种潜在致癌物的解毒过程，似乎在预防致癌物方面发挥重要作用。不同GSTM1基因型与胃癌风险之间的关联仍存在争议。本研究旨在确定GSTM1基因缺失型与胃癌风险之间的关联。
进行了一项基于医院的回顾性病例对照研究，纳入123例原发性胃癌患者和121例健康对照，通过基于聚合酶链反应的方法从外周血样本中评估GSTM1基因的有无。
胃癌组中GSTM1基因缺失型的频率为59.3%，对照组为45.5%。发现GSTM1基因缺失型携带者患胃癌的风险增加。优势比（OR）为1.752，95%置信区间（CI）=2.963至1.035。
在台湾，GSTM1基因缺失多态性与胃癌的遗传易感性相关。
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