Zhang Xi-Liang, Cui Yong-Hui
Department of Gastroenterology, The First People's Hospital of Shangqiu City, Shangqiu, Henan, People's Republic of China.
Onco Targets Ther. 2015 Apr 28;8:969-75. doi: 10.2147/OTT.S79099. eCollection 2015.
Although a number of studies have been conducted on the association between the GSTM1 null genotype and gastric cancer in People's Republic of China, this association remains elusive and controversial. To clarify the effects of the GSTM1 null genotype on the risk of gastric cancer, an updated meta-analysis was performed in the Chinese population. Related studies were identified from PubMed, Springer Link, Ovid, Chinese Wanfang Data Knowledge Service Platform, Chinese National Knowledge Infrastructure (CNKI), and Chinese Biology Medicine (CBM) up to November 5, 2014. A total of 25 studies including 3,491 cases and 5,921 controls were included in this meta-analysis. Overall, a significant association (odds ratio [OR] =1.47, 95% CI: 1.28-1.69) was found between the null GSTM1 and gastric cancer risk when all studies in Chinese population were pooled into the meta-analysis. In subgroup analyses stratified by quality score, geographic area, and source of controls, the same results were observed. Additionally, a significant association was found both in smokers and non-smokers. This meta-analysis showed that the null GSTM1 may be a potential biomarker for gastric cancer risk in Chinese, and further studies with gene-gene and gene-environment interactions are required for definite conclusions.
尽管在中国已开展了多项关于谷胱甘肽硫转移酶M1（GSTM1）基因缺失型与胃癌关联的研究，但这种关联仍不明确且存在争议。为阐明GSTM1基因缺失型对胃癌风险的影响，我们对中国人群进行了一项更新的荟萃分析。通过检索截至2014年11月5日的PubMed、Springer Link、Ovid、中国万方数据知识服务平台、中国知网（CNKI）和中国生物医学文献数据库（CBM），确定了相关研究。本荟萃分析共纳入25项研究，包括3491例病例和5921例对照。总体而言，当将中国人群的所有研究纳入荟萃分析时，发现GSTM1基因缺失型与胃癌风险之间存在显著关联（比值比[OR]=1.47，95%可信区间：1.28 - 1.69）。在按质量评分、地理区域和对照来源分层的亚组分析中，观察到了相同的结果。此外，在吸烟者和非吸烟者中均发现了显著关联。这项荟萃分析表明，GSTM1基因缺失型可能是中国人胃癌风险的一个潜在生物标志物，需要进一步开展基因 - 基因和基因 - 环境相互作用的研究以得出明确结论。
