Kaliman P A, Okhrimenko S M
Ukr Biokhim Zh (1999). 2005 Mar-Apr;77(2):154-8.
It was found that the glucose-fatty acids cycle functioned under the oxidative stress, caused by injection of cobalt chloride solution in albino rats. This cycle promoted the adaptation of metabolism and rehabilitated the homeostasis under extreme conditions. Its functioning was regulated by prolonged (during 2-24 hours) rise in activity of amino acids catabolism enzymes (e.g. tyrosine aminotransferase, arginase) and activation of glyconeogenesis after the mobilisation of liver glycogen. This contributed to increase in glucose and free fatty acids contents in blood. The latter is additionally provided by lipid mobilisation under stress. Tyrosine aminotransferase activation occurred both on the transcription level and by enabling of other mechanisms, which probably concerned the stabilisation of this enzyme. Preliminary injection of alpha-tocopherol in vivo significantly decreased the rise in tyrosine aminotransferase and arginase activities and the rate of erythrocyte hemolysis but did not disable them in full. This made evident that in regulation of the glucose-fatty acids cycle not only active metabolites of oxygen but also Co ions were directly enabled.
研究发现，在向白化大鼠注射氯化钴溶液所引起的氧化应激状态下，葡萄糖 - 脂肪酸循环发挥作用。该循环促进了代谢适应，并在极端条件下恢复了体内稳态。其功能受氨基酸分解代谢酶（如酪氨酸转氨酶、精氨酸酶）活性长时间（2 - 24小时）升高以及肝糖原动员后糖异生激活的调节。这有助于血液中葡萄糖和游离脂肪酸含量的增加。后者在应激状态下通过脂质动员额外提供。酪氨酸转氨酶的激活在转录水平以及通过启用其他可能与该酶稳定有关的机制而发生。体内预先注射α - 生育酚可显著降低酪氨酸转氨酶和精氨酸酶活性的升高以及红细胞溶血率，但并未完全消除这些变化。这表明在葡萄糖 - 脂肪酸循环的调节中，不仅氧的活性代谢产物，而且钴离子也直接发挥作用。
