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[氯化钴注射诱导氧化应激过程中脂质代谢的变化]

[Changes in lipid metabolism during oxidative stress caused by cobalt chloride injection].

作者信息

Shalamov R V, Zagaĭko A L

机构信息

Kharkov State University, Ukraine.

出版信息

Ukr Biokhim Zh (1978). 1998 Jul-Aug;70(4):68-79.

PMID:9848204
Abstract

The cobalt chloride influence on rat liver and serum blood lipids and lipoproteins content and composition was investigated. The data obtained show that the cobalt chloride injection leads to the oxidative stress development and to activation of lipid transport and metabolism. It has been shown that there is system of lipids homeostasis in the organism and it is activated under conditions of oxidative stress. The system blood lipoproteins and liver lipoproteins was found to participate in metabolism adaptation on oxidative stress and in maintenance of biological membranes structure and functioning.

摘要

研究了氯化钴对大鼠肝脏及血清血脂和脂蛋白含量与组成的影响。所得数据表明,注射氯化钴会导致氧化应激的发展以及脂质转运和代谢的激活。已经表明,机体中存在脂质稳态系统,并且在氧化应激条件下该系统会被激活。发现血液脂蛋白和肝脏脂蛋白系统参与了对氧化应激的代谢适应以及生物膜结构和功能的维持。

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